# Determining the role for lncRNAs in controlling inflammation

> **NIH NIH R21** · UNIVERSITY OF CALIFORNIA SANTA CRUZ · 2020 · $185,659

## Abstract

The aim of this proposal is to identify and characterize novel long noncoding RNAs (lncRNAs) that function
to control inflammation and viability in macrophages. Macrophages are critical effector cells of the innate
immune system where they function to control infection and maintain tissue homeostasis. In Aim 1 we will
perform an unbiased screen to knockdown all lncRNAs in human or murine macrophages using CRISPRi
technology and determine those that function to control NFκB, the master regulator of inflammatory genes.
In Aim 2 of this proposal we will identify all lncRNAs required for macrophage viability in humans and mice.
We will determine the mechanism of actions of our top conserved candidates. This proposal will allow for
rapid meaningful data on the role that lncRNAs play in macrophage biology to be obtained in a highly
efficient manner.

## Key facts

- **NIH application ID:** 9966868
- **Project number:** 5R21AI142165-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA SANTA CRUZ
- **Principal Investigator:** Susan Carpenter
- **Activity code:** R21 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $185,659
- **Award type:** 5
- **Project period:** 2019-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9966868

## Citation

> US National Institutes of Health, RePORTER application 9966868, Determining the role for lncRNAs in controlling inflammation (5R21AI142165-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9966868. Licensed CC0.

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