# TR&D2: Field-cycling relaxometry

> **NIH NIH P41** · NEW YORK STRUCTURAL BIOLOGY CENTER · 2020 · $174,716

## Abstract

TR&D 2 - Field-cycling relaxometry
Summary
The “Center on Macromolecular Dynamics by NMR Spectroscopy” (CoMD/NMR) will install the
world's first field-cycling shuttle system for an 800 MHz NMR spectrometer, to be sited at the New
York Structural Biology Center. This instrument will enable applications of relaxometry to DBPs, to
significantly increase knowledge of the relevant spectral density functions and therefore allow much
more detailed investigations of macromolecular conformational dynamics. Relaxometry is a
technique in which a sample is polarized at high static magnetic field, then physically moved to low
field for a relaxation period, and subsequently returned to high field for detection. Activities in this
TR&D will include evaluation of alternative shuttle designs, development of novel experimental
strategies for use of the shuttle probe, and iterative development and validation of analysis
approaches to interpret relaxometric data for the DBPs.

## Key facts

- **NIH application ID:** 9967026
- **Project number:** 5P41GM118302-04
- **Recipient organization:** NEW YORK STRUCTURAL BIOLOGY CENTER
- **Principal Investigator:** ARTHUR G PALMER
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $174,716
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967026

## Citation

> US National Institutes of Health, RePORTER application 9967026, TR&D2: Field-cycling relaxometry (5P41GM118302-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9967026. Licensed CC0.

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