# National Resource For Advanced NMR Technology

> **NIH NIH P41** · FLORIDA STATE UNIVERSITY · 2020 · $1,034,604

## Abstract

National Resource for Advanced NMR Technology
OVERALL - Project Summary/Abstract
 Nuclear magnetic resonance (NMR) spectroscopy is a unique set of experimental tools for understanding
the intricacies of biology from macromolecular complexes to complex mixtures, from atomic resolution
structure to dynamics on timescales of picoseconds to kiloseconds, from chemistry to functional mechanisms
and kinetic rates. No other technology has such breadth and potential for basic and applied research and for
interfacing with other technologies, such as X-ray crystallography, small angle X-ray scattering, Cryo-EM, and
many other spectroscopic tools. Structural characterization serves as the starting point, providing a framework
for understanding biological activities, functional mechanisms and kinetic models that can be added by NMR.
Dynamics can be exceptionally well characterized by NMR and this can lead to detailed understanding about
how proteins and other macromolecules function, how complexes are formed, and sometimes how kinetic
rates are achieved. The solution NMR spectroscopy of complex mixtures has been shown to be particularly
useful in combination with mass spectrometry for metabolomics and other complex mixtures. Here, we focus
on the frontiers of NMR technology made possible by recent breakthroughs in materials research and
instrumentation, and their implementation for a broad user community interested in pursuing fundamental
questions at atomic resolution at the forefront of biomedical research.
 Three TR&Ds advance the sensitivity of NMR each with novel technology – the first through use of high
temperature superconductors for RF coils leading to unique sensitivity for solution NMR spectroscopy. TR&D2
takes advantage of a 600 MHz DNP instrument recently installed at the Magnet Lab that will provide enhanced
sensitivity through the transfer of magnetization from electrons to protons. New and much more robust DNP
probes with an expanded temperature range will be developed. TR&D3 takes advantage of the 36T Series
Connected Hybrid for NMR spectroscopy – a jump in field strength of more that 50% equivalent to a jump in
field strength from 17T (1990) to 23.5T (2016) that occurred over the past 26 years! This will lead to dramatic
enhancements in sensitivity and even more spectacular reductions in signal averaging time. The science will
be driven by an excellent team of DBPs and even more C&Ss that span a very broad range of science. A
major team effort will be placed on training a new generation of NMR users through an annual pair of
workshops and dissemination through publications and presentations at meetings, through a wide variety of
scientific organizations and the news media; through a dedicated website for this Resource and through our
training activities; as well as posting of our training lectures and video of demonstrations.

## Key facts

- **NIH application ID:** 9967068
- **Project number:** 5P41GM122698-04
- **Recipient organization:** FLORIDA STATE UNIVERSITY
- **Principal Investigator:** William W Brey
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,034,604
- **Award type:** 5
- **Project period:** 2017-08-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967068

## Citation

> US National Institutes of Health, RePORTER application 9967068, National Resource For Advanced NMR Technology (5P41GM122698-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9967068. Licensed CC0.

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