# TR&D1-HTS

> **NIH NIH P41** · FLORIDA STATE UNIVERSITY · 2020 · $290,531

## Abstract

Project Summary/Abstract
TR&D1
The goal of this project is to develop high sensitivity probes based on superconducting
resonators for direct detection in metabolomics and in protein structure NMR. For
metabolomics, we will develop a probe which is sensitive on both 2H and 13C channels. This
probe will be used for isotopomer analysis to assess metabolic changes. For protein structure
NMR, the probe will be optimized for efficient detection of 15N. This probe will be designed to
exploit the recently described TROSY-based line narrowing effect for 15N at high field, an effect
which will be important for structure characterization of intrinsically disordered and membrane-
associated proteins. We will also use these probes as technology development projects to
improve the performance of superconducting resonators in NMR probes.

## Key facts

- **NIH application ID:** 9967074
- **Project number:** 5P41GM122698-04
- **Recipient organization:** FLORIDA STATE UNIVERSITY
- **Principal Investigator:** William W Brey
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $290,531
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967074

## Citation

> US National Institutes of Health, RePORTER application 9967074, TR&D1-HTS (5P41GM122698-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9967074. Licensed CC0.

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