# Venous Waveform Analysis to Predict Volume Overload

> **NIH NIH R01** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $425,000

## Abstract

PROJECT SUMMARY
In the perioperative environment, precise control of intravascular volume status is important. It
has been demonstrated that both volume overload and under resuscitation in the perioperative
period can increase morbidity, mortality, length of stay, and cost of perioperative care.
Unfortunately, clinical signs and current monitoring strategies are unreliable in providing
accurate, real time assessments of volume status. This proposal will develop the use of a
unique physiologic signal, Non-Invasive Venous waveform Analysis (NIVA), for monitoring
intravascular volume status of both hemorrhage and volume overload. Proof of concept data in
humans and experimental animal models, demonstrate that NIVA provides a reliable indication
of intravascular volume status, supporting the premise of this proposal. This proposal will use an
experimental porcine model of controlled hemorrhage, resuscitation, and volume overload
resuscitation to validate and refine an algorithm for waveform analysis. NIVA will be tested in
further porcine studies and bench-top human saphenous veins in an ex vivo flow loop with a
simulated extracellular matrix as a controlled model system to determine limitations and
mechanisms of NIVA. These studies will be used to mitigate risks associated with the use of
NIVA and will lead to a better understanding of venous waveform analysis (for precise
management of intravascular volume) and of venous hemodynamics (a largely under studied
part of the cardiovascular system).

## Key facts

- **NIH application ID:** 9967086
- **Project number:** 5R01HL148244-02
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Bret D. Alvis
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $425,000
- **Award type:** 5
- **Project period:** 2019-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967086

## Citation

> US National Institutes of Health, RePORTER application 9967086, Venous Waveform Analysis to Predict Volume Overload (5R01HL148244-02). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9967086. Licensed CC0.

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