# Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism

> **NIH NIH R01** · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2020 · $735,956

## Abstract

   
DESCRIPTION (provided by applicant): In a recent double-blind placebo-controlled study we found the broad spectrum anticonvulsant zonisamide (ZON) to have effects on ethanol consumption that are comparable to those of topiramate. We hypothesize here that the administration of ZON, by attenuating the hyperexcitability of the brain during periods of abstinence, through its neuro-protective effects, and its enhancement of dopamine activity in midbrain and frontal regions will counteract the effects of alcohol that lead to impaired regulatio of emotional and reward processes that control the consumption of alcohol. This will be evident by the normalization of brain activity seen in performance of the alcohol and emotional-word Stroop tasks and in a reduction of the BOLD response to alcohol related images. The results of this study should provide an indication of the neurobehavioral mechanisms through which ZON may act to regulate the consumption of alcohol.

## Key facts

- **NIH application ID:** 9967905
- **Project number:** 5R01AA015923-10
- **Recipient organization:** BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- **Principal Investigator:** Todd J. Farchione
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $735,956
- **Award type:** 5
- **Project period:** 2005-12-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967905

## Citation

> US National Institutes of Health, RePORTER application 9967905, Interdisciplinary Study of Two Novel Anticonvulsants in Alcoholism (5R01AA015923-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9967905. Licensed CC0.

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