# Core A Scientific and Administrative Integration: Thymic and peripheral Aspects of T cell Aging and Rejuvenation

> **NIH NIH P01** · UNIVERSITY OF ARIZONA · 2020 · $127,331

## Abstract

The success of multidisciplinary, multi-investigator scientific programs critically depends not only on the
scientific quality of the individual research programs and their thematic synergy, but equally on the ability of the
group to work together and to stay on course to accomplish larger goals of the common endeavor. Even
greater scientific advancements are possible if teams can enhance the quality of science by cross-fertilization
of ideas and the potential to draw new conclusions from cross-analysis of data contributed by studying different
components of the same system (organism). Coordination of the above issues is particularly critical when the
area of research lies at an interface of two complex disciplines, as is clearly the case with immunology and
gerontology research. All of the above necessitates a deliberate and systematic approach to ensure Program
success at all levels.
 To that effect, the Scientific Integration and Administration Core (Core A) will be the nerve center of the
Program, coordinating every aspect of its scientific and administrative progress. Specific Aims are to:
 SA1. Ensure scientific communication and exchange via: (i) regular monthly group videoconference
 meetings; (ii) a common and interactive experimental planning and data sharing space – the Thymus
 Rejuvenation PPG Wiki and (iii) annual in-person PPG progress meetings. Thes Core will also organize
 and promote animal, tissue and reagent sharing via the above Wiki.
 SA2. Ensure fiscal and administrative oversight by monitoring spending with regard to specific aims
 and productivity of individual Projects and ensure timely annual reporting to the sponsor.
 SA3. Organize and implement scientific oversight. via (i) an internal PPG Scientific Steering Committee
 (PSSC), consisting of Project Leaders; and (ii) an external advisory board (EAB) composed of 3-4
 scientists with strong expertise in the area of the Program.
 SA 4. Provide coordinated data and knowledge sharing and management platforms to enable the
 distributed team members to securely share and manage data sets ; and to allow teams to document
 experimental progress and results, and share laboratory protocols and datasets. This SA will also host and
 perform version control of MiCASA morphometric software and organize training of Program personnel by
 P1 staff. The platforms will be aligned to the needs of Core B and will be optimized via controlled
 ontologies, standardized meta-data collection, and common ID conventions to facilitate data mining, cross-
 fertilization and cross-discovery, by answering a series of specific inter-project questions formulated by the
 Program Scientific Steering Committee.
This Core will therefore foster scientific integration at the highest level, while providing administrative cohesion.

## Key facts

- **NIH application ID:** 9967933
- **Project number:** 5P01AG052359-04
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** JANKO Z. NIKOLICH
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $127,331
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967933

## Citation

> US National Institutes of Health, RePORTER application 9967933, Core A Scientific and Administrative Integration: Thymic and peripheral Aspects of T cell Aging and Rejuvenation (5P01AG052359-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9967933. Licensed CC0.

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