# Clinical Core

> **NIH NIH P30** · CLEVELAND CLINIC LERNER COM-CWRU · 2020 · $808,433

## Abstract

CLINICAL CORE
CLINICAL CORE PROJECT SUMMARY
 The Cleveland Alzheimer’s Disease Research Center’s (CADRC) theme is to further understanding of
the brain-behavior correlations and the biology underlying the heterogeneity of Alzheimer’s disease (AD). The
Clinical Core (CC) will focus on populations that provide special insights into this broad goal and meet the general
responsibilities of a clinical core, which include enrolling, characterizing, and following longitudinally a diverse
population of older individuals. These subjects will receive a comprehensive UDS evaluation, and provide MRI
and PET data, fluid biomarkers, and autopsy confirmation of diagnosis.
 The CC goals are integrated with overall center goals and include developing clinical data to assist in
meeting the aims of the CADRC. A major focus of the CC will be to develop a Clinical Core Registry (CCR) that
will focus on populations including individuals with rapidly progressive AD (rpAD), Dementia with Lewy Bodies,
professional fighters, cognitively normal APOE ε4 carriers and non-carriers, and African Americans. Other
innovations include use of teleneurology evaluations, particularly subjects with rpAD, who are unable to come to
in-person evaluations. Collection of biomarkers to improve and provide diagnostic accuracy, and allow for
detailed ‘-omics’ type analyses on these subjects will help us understand the basis for AD heterogeneity.
 In coordination with the Data Management and Statistics Core (DMSC) the CC will be the source for
high quality patient data for the other CADRC cores and the National Alzheimer’s Coordinating Center (NACC).
The inclusion of the Lou Ruvo Center for Brain Health in Las Vegas, NV extends our geographical reach and
minority outreach and engagement, and taps into the ongoing professional fighters’ study, which includes
substantial minority representation. Inclusion of the Cleveland VA medical center and its Geriatric Research and
Education Clinical Center (GRECC) will also boost minority enrollment.
 Individuals will be tracked across studies, adding value to the overall information content. Adding further
value will be collaboration with the Neuropathology and Biomarker Cores to collect linked biospecimens and
support the brain autopsy program to advance brain-behavior correlations.
 Accessibility to data and biospecimens of CCR participants for internal and external investigators will be
improved by linking efforts across all cores and components. The CC will advance AD research by supporting
pilot projects funded through the ADRC and, in collaboration with the Research Education Component (REC,
train new scientists using structured evaluations, clinical care, and research in a trainee-friendly environment.
 As implemented the mission, vision, and research goals of the CC over the next five years are well-
integrated into the ADRC’s specific goals, and align with the National Alzheimer’s Action Plan and recent
initiatives to increase coordination among ...

## Key facts

- **NIH application ID:** 9967975
- **Project number:** 5P30AG062428-02
- **Recipient organization:** CLEVELAND CLINIC LERNER COM-CWRU
- **Principal Investigator:** Alan J Lerner
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $808,433
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9967975

## Citation

> US National Institutes of Health, RePORTER application 9967975, Clinical Core (5P30AG062428-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9967975. Licensed CC0.

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