# Collaboratory of AIDS Researchers for Eradication (CARE)

> **NIH NIH UM1** · UNIV OF NORTH CAROLINA CHAPEL HILL · 2020 · $4,592,950

## Abstract

Abstract
 Despite the clinical success of antiretroviral therapy (ART), more people contract human
immunodeficiency virus (HIV) infection daily than initiate ART. Since its inception in 2011, the Martin Delaney
Collaboratory program has made important advances towards a cure for HIV, a much-needed effort to
comprehensively combat the AIDS pandemic. The 2016 scientific agenda of the Collaboratory of AIDS
Researchers for Eradication (CARE) seeks to more rapidly advance approaches for latency disruption and
clearance into clinical testing. We hypothesize that the latent state of HIV can be reversed such that antigenic
viral proteins are expressed, and that this intervention must be strategically combined with immunotherapies to
allow the clearance of cells emerging from latency. Effective implementation of this strategy is expected to
lead to the eradication of persistent HIV infection, a cure for AIDS. Our group now possesses substantial
expertise previously not brought to bear on this problem, including the skills and tools of an expanded group of
pharmaceutical partners. Our initial efforts will focus on the key objectives to facilitate clinical trials of
eradication therapy: Detection of HIV antigen-positive cells (IRF I), Clearance of HIV antigen-positive cells (IRF
II), Revealing and Clearing Unseen HIV (IRF 3).
 We envision an iterative process with insights gained in ex vivo, pre-clinical and clinical experiments
carried forward to enhance the next step in clinical development and, importantly, fed back to scientists to
refine their work, validate assays or hypotheses, and explore new directions. We are dedicated to working
together in a nimble program, able to alter the course of our research as directed by our discoveries, convinced
that together we will catalyze advances that will ultimately lead to the eradication of HIV infection.

## Key facts

- **NIH application ID:** 9968000
- **Project number:** 5UM1AI126619-05
- **Recipient organization:** UNIV OF NORTH CAROLINA CHAPEL HILL
- **Principal Investigator:** DAVID M. MARGOLIS
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $4,592,950
- **Award type:** 5
- **Project period:** 2016-07-14 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9968000

## Citation

> US National Institutes of Health, RePORTER application 9968000, Collaboratory of AIDS Researchers for Eradication (CARE) (5UM1AI126619-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/9968000. Licensed CC0.

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