# Genomics and Bioinformatics Shared Resource

> **NIH NIH P30** · UNIVERSITY OF HAWAII AT MANOA · 2020 · $122,106

## Abstract

ABSTRACT
 The Genomics and Bioinformatics Shared Resource (GBSR) at the University of Hawai‘i Cancer Center
(UHCC) has been supported by the CCSG since 1999. It started as a genotyping facility, but now offers a
broad array of high-end genomic analyses, on both the microarray and ultra-deep sequencing platforms. These
are services that are not commercially available in Hawai‘i. In the past grant cycle, the bioinformatics
component was added and a co-director was recruited to provide state-of-the art bioinformatics analysis of
“omics” data. This greatly enhances the capacity and depth of high-throughput data analysis services at UHCC
and provides the only integrated and comprehensive resource for genomic sequencing and data analysis in the
State. During the current grant period, the GBSR has expanded its services from genotyping to a number of
other genomic analyses. Currently, the GBSR provides nucleic acid isolation and quality analysis, genotyping,
and also gene expression, copy number alteration and methylation analysis services in support of the peer-
reviewed and IRB-approved research conducted by UHCC members. A variety of assays are performed on
samples from cancer biology studies as well as on those collected in epidemiological and clinical studies that
take advantage of the genetic heterogeneity of multiethnic populations, especially from Hawai'i. The scale of
these studies varies from a few to tens of thousands of samples, the focus ranges from a single SNP or gene
to genome-wide, and the assays performed on each sample range from one to over a million. The goal is to
translate information now available on the human genome into new knowledge about cancer etiology,
prevention and treatment. With the addition of several microarray platforms the GBSR has significantly
extended the range of its services and is serving a larger number of users (including basic science
investigators) at UHCC. An Illumina NextSeq 500 Next Generation Sequencer (NGS) service was purchased
during this last cycle and became operational in March 2017. The GBSR reduces redundancies at the Center
by furnishing a central service that uses cutting edge and high-throughput technologies. In addition, the
personnel of the GBSR can provide project planning advice and troubleshooting capabilities during the
execution of the projects. The personnel of the GBSR are highly knowledgeable in the areas of molecular
biology and genetics, and can provide both the novice and the advanced users with a level of technical
support, consultation and information services that are not found elsewhere in Hawai'i.

## Key facts

- **NIH application ID:** 9968045
- **Project number:** 5P30CA071789-20
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** Maarit Inkeri Tiirikainen
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $122,106
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9968045

## Citation

> US National Institutes of Health, RePORTER application 9968045, Genomics and Bioinformatics Shared Resource (5P30CA071789-20). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9968045. Licensed CC0.

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