# Comparative Cognition and Hippocampal Function

> **NIH NIH R01** · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · 2020 · $412,500

## Abstract

PROJECT SUMMARY/ABSTRACT
The hippocampus plays a critical role in the organization of memories. Previous studies on the nature of
neural representations in the hippocampus have focused on spatial representations by hippocampal neurons,
but many studies in humans and animals indicate a broader role for the hippocampus in memory organization.
Representational Similarity Analysis, which has been very successful in revealing the organization of neural
representations in other domains, will be employed to explore how hippocampal networks organize memories
that are distinguished by temporal context and by specific salient cues and rules; and how multiple memory
representations are integrated and stabilized over time. These experiments employ a combination of multi-
electrode recording in rats, state-of-the-art calcium imaging in behaving mice, and novel neural population
analyses, to generate a new understanding of neural network representations. These studies are of high
translational potential because cognition dependent on memory organization is impaired in mental disorders
including schizophrenia.

## Key facts

- **NIH application ID:** 9968442
- **Project number:** 5R01MH052090-25
- **Recipient organization:** BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
- **Principal Investigator:** Michael E Hasselmo
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $412,500
- **Award type:** 5
- **Project period:** 1994-09-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9968442

## Citation

> US National Institutes of Health, RePORTER application 9968442, Comparative Cognition and Hippocampal Function (5R01MH052090-25). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9968442. Licensed CC0.

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