# Prox1 in Mammalian Lymphangiogenesis

> **NIH NIH R01** · NORTHWESTERN UNIVERSITY · 2020 · $395,000

## Abstract

Summary
Development of the mammalian lymphatic vasculature is a stepwise process requiring
the specification of lymphatic endothelial cell progenitors in the embryonic veins, and
their subsequent budding to give rise to most of the mature lymphatic vasculature. In
mice, formation of the lymphatic vascular network starts inside the cardinal vein at
around E9.5 when a subpopulation of venous endothelial cells get committed into the
lymphatic lineage by their acquisition of Prox1 expression. Here we will continue with our
long-time efforts to accomplish a detailed cellular and molecular characterization of the
genes and mechanisms regulating the early steps leading to the formation of the
mammalian lymphatic vasculature. A better understanding of basic aspects of early
lymphatic development and the availability of novel tools and animal models has been
instrumental in the identification of important novel functional roles of the lymphatic
vasculature.

## Key facts

- **NIH application ID:** 9969240
- **Project number:** 5R01HL073402-19
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** GUILLERMO C OLIVER
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $395,000
- **Award type:** 5
- **Project period:** 2003-05-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9969240

## Citation

> US National Institutes of Health, RePORTER application 9969240, Prox1 in Mammalian Lymphangiogenesis (5R01HL073402-19). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9969240. Licensed CC0.

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