# Neuropathology Core

> **NIH NIH P30** · MAYO CLINIC ROCHESTER · 2020 · $224,346

## Abstract

PROJECT DESCRIPTION/ABSTRACT – NEUROPATHOLOGY CORE
The Neuropathology (NP) Core performs diagnostic evaluations, quantitative analyses on brain tissue
collected at autopsy of participants in the Mayo Alzheimer Disease Research Center (ADRC), and genetic
testing of known and novel genetic variants. The NP Core provides support to ADRC-affiliated investigators
and to outside investigators. The neuropathologic and genetic data generated by the NP Core is
communicated to the Data Management and Statistical Core, who uploads it to the National Alzheimer
Coordinating Center. The research approach for the NP Core is as follows: Specific Aim 1. Perform brain
autopsies on participants of the Mayo ADRC in a timely fashion and according to protocol, which includes
collection of fixed and frozen tissue. Specific Aim 2. Provide neuropathologic evaluations and collect
neuropathologic data using standardized methods for gross dissection and neurohistology. Assign AD
likelihood diagnoses based upon Thal amyloid phase, Braak NFT stage, and CERAD neuritic plaque score
using the NIA-AA diagnostic probability scheme. Arrive at a consensus on clinicopathologic diagnoses at
videoconferences. Record neuropathologic data on NACC Version 10 and provide to the Data Management
and Statistical Core and NACC. Specific Aim 3. Generate quantitative endophenotypes using digital
pathology and image analysis in support of ADRC research. Specific Aim 4. Store brain tissue and other
autopsy-derived materials and provide clinically and pathologically well-characterized tissue samples to
investigators at Mayo Clinic and outside institutions. Assure security of biologic samples by using continuous
electronic monitoring of freezers and by maintaining at all times at least one empty back-up freezer.
Specific Aim 5. Provide genetic expertise to ADRC, as well as screening for known and newly discovered
genes or common genetic risk variants for AD, Lewy body disorders (LBD) and frontotemporal lobar
degenerations (FTLD).

## Key facts

- **NIH application ID:** 9969332
- **Project number:** 5P30AG062677-02
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** DENNIS WILLIAM DICKSON
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $224,346
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9969332

## Citation

> US National Institutes of Health, RePORTER application 9969332, Neuropathology Core (5P30AG062677-02). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9969332. Licensed CC0.

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