# Cortical computations underlying binocular motion integration > **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2020 · $399,500 ## Abstract PROJECT SUMMARY / ABSTRACT Neuroscience is highly specialized—even visual submodalities such as motion, depth, form and color processing are often studied in isolation. One disadvantage of this isolation is that results from each subfield are not brought together to constrain common underlying neural circuitry. Yet, to understand the cortical computations that support vision, it is important to unify our fragmentary models that capture isolated insights across visual submodalities so that all relevant experimental and theoretical efforts can benefit from the most powerful and robust models that can be achieved. This proposal aims to take the first concrete step in that direction by unifying models of direction selectivity, binocular disparity selectivity and 3D motion selectivity (also known as motion-in-depth) to reveal circuits and understand computations from V1 to area MT. Motion in 3D inherently bridges visual submodalities, necessitating the integration of motion and binocular processing, and we are motivated by two recent paradigm-breaking physiological studies that have shown that area MT has a robust representation of 3D motion. In Aim 1, we will create the first unified model and understanding of the relationship between pattern and 3D motion in MT. In Aim 2, we will construct the first unified model of motion and disparity processing in MT. In Aim 3, we will develop a large-scale biologically plausible model of these selectivities that represents realistic response distributions across an MT population. Having a population output that is complete enough to represent widely-used visual stimuli will amplify our ability to link to population read-out theories and to link to results from psychophysical studies of visual perception. Key elements of our approach are (1) an iterative loop between modeling and electrophysiological experiments; (2) building a set of shared models, stimuli, data and analysis tools in a cloud-based system that unifies efforts across labs, creating opportunities for deep collaboration between labs that specialize in relevant submodalities, and encouraging all interested scientists to contribute and benefit; (3) using model-driven experiments to answer open, inter-related questions that involve motion and binocular processing, including motion opponency, spatial integration, binocular integration and the timely problem of how 3D motion is represented in area MT; (4) unifying insights from filter-based models and conceptual, i.e., non-image- computable, models to generate the first large-scale spiking hierarchical circuits that predict and explain how correlated signals and noise are transformed across multiple cortical stages to carry out essential visual computations; and (5) carrying out novel simultaneous recordings across visual areas. This research also has potential long-term benefits in medicine and technology. It will build fundamental knowledge about functional cortical circuitry that someday may be useful... ## Key facts - **NIH application ID:** 9969438 - **Project number:** 5R01EY027023-04 - **Recipient organization:** UNIVERSITY OF WASHINGTON - **Principal Investigator:** Wyeth Daniel Bair - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2020 - **Award amount:** $399,500 - **Award type:** 5 - **Project period:** 2017-09-30 → 2022-06-30 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/9969438 ## Citation > US National Institutes of Health, RePORTER application 9969438, Cortical computations underlying binocular motion integration (5R01EY027023-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9969438. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*