# Analytical Chemistry

> **NIH NIH P30** · UNIVERSITY OF ARIZONA · 2020 · $107,799

## Abstract

Project Summary / Abstract: Analytical Chemistry Shared Resource (ACSR)
The goal of Analytical Chemistry Shared Resource (ACSR), which was established in 2001, is to enhance the
capabilities and productivity of University of Arizona Cancer Center investigators by providing a cutting-edge
centralized Resource to perform analytical chemistry assays for small molecules (<1000 daltons) and
pharmacokinetic and pharmacodynamic data analysis and interpretation. The ACSR has accumulated
considerable expertise in quantitative analysis of small molecules, including drugs and exogenous and
endogenous chemicals in biological specimens, using chromatography-mass spectrometry-based systems and
in the development of analytical assay protocols tailored to the needs of UACC investigators. The ACSR
provides the following services: 1) consultation on study design including selection of assays and / or
development of new assays, coordination with activities of other Shared Resources, and data analysis; 2)
development, validation and implementation of cancer-related bioanalytical assays; 3) performance of
quantitative and qualitative analysis of cancer therapeutic and preventive agents, nutrients, carcinogens,
endogenous biochemical, and imaging agents; 4) pharmacokinetic study design and PK and PD data analysis;
5) metabolomic profiling. During the current grant period, the ACSR has continued to build its repository of
analytical assay protocols, many of which can be readily applied to new projects, and thus, the ACSR is able to
support a broad spectrum of research projects in a cost-effective manner and with a rapid turnaround time. The
leadership of the ACSR is responsive to research needs of the UACC investigators. In the current grant period,
this has included the development and implementation of state-of-the-art metabolomic analyses. Services
provided by the ACSR are essential for the assessment of drug/nutrient/carcinogen exposure and disposition,
and for the measurement of endogenous biochemicals as surrogate cancer-risk biomarkers and endpoint
biomarkers in intervention studies. These measurements are indispensable in many established lines of
research at the UACC, including preclinical and clinical evaluation of cancer therapeutic drugs and preventive
interventions, assessment of biological, environmental, and lifestyle factors associated with cancer risk and
disease progression, and identification of potential targets for intervention.

## Key facts

- **NIH application ID:** 9969484
- **Project number:** 5P30CA023074-40
- **Recipient organization:** UNIVERSITY OF ARIZONA
- **Principal Investigator:** H-H. Sherry CHOW
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $107,799
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9969484

## Citation

> US National Institutes of Health, RePORTER application 9969484, Analytical Chemistry (5P30CA023074-40). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9969484. Licensed CC0.

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