# Local and systemic regulation of hematopoietic stem cells by thrombopoietin

> **NIH NIH F30** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $50,520

## Abstract

Project Summary:
Hematopoietic stem cells (HSCs) are a critical and rare population of cells that can self-
renew extensively and produce all blood cell lineages. HSCs are maintained and
regulated throughout life by extrinsic regulation; disruption of this regulation can lead to
loss of HSCs and hematopoietic failure. Thus, understanding HSC extrinsic regulatory
mechanisms has important therapeutic implications. Thrombopoietin (TPO) is a
hematopoietic cytokine that is canonically understood as a driver of megakaryocyte
proliferation and platelet production, but has also been shown to be required for HSC
maintenance. However, since TPO is made in the bone marrow, the liver and other
tissues, the relative contributions of local and systemic TPO to HSC function are still
unknown. This project aims to characterize the in vivo role of TPO in HSC biology by use
of two novel mouse models that allow identification of TPO+ populations in the bone
marrow, and conditional deletion of Tpo from select tissues. The experiments in this
proposal will define the role of TPO in HSC biology, and have major implications for
clinical therapies that take advantage of our novel understanding of how HSC regulation
is balanced between local and systemic factors.

## Key facts

- **NIH application ID:** 9969552
- **Project number:** 5F30HL137323-04
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Matthew Decker
- **Activity code:** F30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $50,520
- **Award type:** 5
- **Project period:** 2017-07-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9969552

## Citation

> US National Institutes of Health, RePORTER application 9969552, Local and systemic regulation of hematopoietic stem cells by thrombopoietin (5F30HL137323-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9969552. Licensed CC0.

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