# Administrative Core

> **NIH NIH P50** · CHILDREN'S RESEARCH INSTITUTE · 2020 · $245,013

## Abstract

Abstract:
The Administrative Core (Core A) will be managed by John van den Anker, Center Director, and Eric
Hoffman, Director Pilot Programs. Dr. van den Anker is the Vice Chair of Pediatrics for Experimental
Therapeutics at Children’s National Health System (CNHS) and brings expertise in the management of
programs such as the Pediatric Pharmacology Research Unit and the current specialized center in
Research in Pediatric Developmental Pharmacology (RPDP), and has extensive clinical and research
expertise in several areas of developmental and pediatric pharmacology. He also serves as the Co-I of
Project 1 (Basic/Translational Project; Dissociation of efficacy from side effects of anti-inflammatory
therapies in Duchenne muscular dystrophy), and Project 2 (Clinical Project; Bridging pharmacodynamics
biomarkers to endoscopic and clinical outcomes in pediatric inflammatory bowel disease). Dr. Hoffman is
the founding Chair of the Department of Integrative Systems Biology at George Washington University,
and the Director of Genetic Medicine at CNHS, and is currently the CEO of ReveraGen (leave of
absence from CNMC until early 2017). Dr. Hoffman brings extensive expertise in pediatric drug
development, clinical trials, clinical/translational research specifically in the area of DMD, and
pharmacodynamics of steroids. He will also serve as the MPI of Project 1. Drs. Van den Anker and
Hoffman have complementary capabilities that will allow them to effectively direct the Administrative Core.
This Core has three specific aims. In Specific Aim 1, fiscal management of all Projects and the
Administrative Core, oversight of balancing of Core resources, convening of the Internal Steering
Committee as well as annual meetings of the External Advisory Board, and solicitation and reviewing of
Pilot Project applications will be the responsibility of Dr. van den Anker and his administrative team. In
Specific Aim 2, monthly conference calls of key personnel on all Projects and the Administrative Core,
monitoring of research progress on each Project and Core, including timely achievement of milestones,
oversight of annual scientific reports, and oversight and monitoring of human subjects and regulatory
compliance will be carried out. In Specific Aim 3, Dr .Hoffman will manage the RPDP Pilot Program.
Finally, both Drs. van den Anker and Hoffman are tightly integrated into the CTSA efforts and this very
active involvement of the CTSA within the RPDP investigations will ensure synergism with this nationally-
based clinical and translational research effort.

## Key facts

- **NIH application ID:** 9970244
- **Project number:** 5P50HD090254-05
- **Recipient organization:** CHILDREN'S RESEARCH INSTITUTE
- **Principal Investigator:** JOHANNES NICOLAAS VAN DEN ANKER
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $245,013
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9970244

## Citation

> US National Institutes of Health, RePORTER application 9970244, Administrative Core (5P50HD090254-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9970244. Licensed CC0.

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