# BIOLOGICAL BASES OF ALCOHOLISM

> **NIH NIH T32** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $509,504

## Abstract

Project Summary / Abstract
The overarching aim of this pre- and post-doctoral training program is to develop specialists who are able to
conduct basic research at levels ranging from the molecular to the cognitive/clinical, on the biological
mechanisms underlying the etiology, treatment and prevention of alcohol (ethanol) use disorders. Twenty-two
members of the graduate faculty of the Oregon Health & Science University (OHSU) serve as preceptors for
predoctoral students and postdoctoral research fellows in two graduate programs at OHSU—Behavioral
Neuroscience, and the Neuroscience Graduate Program. Major research interests represent five areas of
common interest: (1) genetic bases for ethanol responses and risk, (2) learned and unlearned determinants of
ethanol reward, (3) neurobiological bases for the rewarding, aversive and neuropathological effects of ethanol,
(4) neuroadaptive mechanisms associated with repeated and/or developmental ethanol exposure, ethanol
dependence and sensitization, and (5) effects of ethanol on memory and cognition. In addition, comparison to
the effects of other drugs of abuse is of significant interest. Technical strategies reflect four levels of analysis: I.
Behavioral pharmacological/pharmacogenetic, II. Neurochemical/neurophysiological/ neuropharmacological,
III. Cellular/molecular biological and IV. Cognitive neuroscience/social, including human/clinical level.
Coordinated research efforts within the Portland Alcohol Research Center (PARC) and the Integrative
Neuroscience Initiative on Alcoholism (INIA) have strengthened training by unifying investigators and creating
multidimensional research projects. Training includes firm curricular grounding in the basic sciences, specific
pharmacological training in ethanol and other abused drugs, and extensive and continuous participation in
research. Six predoctoral trainees per year, beginning with 0-2 years of graduate experience, will be supported
by the training grant for 2-3 years, and then by individual National Research Service Awards or their mentors'
resources. Three postdoctoral trainees per year with 1-3 years of postdoctoral experience will be supported by
the training grant for 2 years. We have a well-developed plan for improving the diversity of our trainees and all
trainees are expected to complete an initial intensive course in the Responsible Conduct of Research, as well
as continuing education in this area. Ample opportunities exist for our trainees to be involved in public
education and outreach.

## Key facts

- **NIH application ID:** 9970362
- **Project number:** 5T32AA007468-34
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Andrey E Ryabinin
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $509,504
- **Award type:** 5
- **Project period:** 1987-09-30 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9970362

## Citation

> US National Institutes of Health, RePORTER application 9970362, BIOLOGICAL BASES OF ALCOHOLISM (5T32AA007468-34). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9970362. Licensed CC0.

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