# Gene Expression Analysis Core

> **NIH NIH P01** · INTERNATIONAL AIDS VACCINE INITIATIVE · 2020 · $451,361

## Abstract

PROJECT SUMMARY (Core C - Gene Expression Signatures) 
HIV has proven its ability to defeat all vaccine candidates tested to date. However, evidence in humans and 
model systems demonstrates that immune system is capable of generating antibodies that neutralize multiple 
HIV-1 viral strains. While the mechanisms that lead to the generation of broadly neutralizing antibodies remain 
to be determined, a number of studies have shown that the early innate immune responses to vaccines are 
predictive of the subsequent adaptive response which is responsible for protection. Thus, transcriptional 
signatures of innate responses can be used to discover gene regulatory networks, or “rules”, driving adaptive 
responses and vaccine efficacy. In this program we seek to comprehensively evaluate, and compare 4 novel 
vaccines that deliver a common HIV immunogen, but differ in their mode of delivery and their potential 
immunostimulatory profiles. We will use early transcriptional signatures (gene signatures) as part of this 
program to reveal the innate immune networks elicited by each vaccine candidate and delivery strategy, to 
correlate vaccine elicited immunogenicity with early innate immune signatures, to provide a framework for 
predicting the efficacy of vaccine candidates, and to lay a foundation for future rational vaccine designed to 
activate desired innate immune responses and subsequent adaptive responses.

## Key facts

- **NIH application ID:** 9970394
- **Project number:** 5P01AI124337-05
- **Recipient organization:** INTERNATIONAL AIDS VACCINE INITIATIVE
- **Principal Investigator:** JOHN D. AITCHISON
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $451,361
- **Award type:** 5
- **Project period:** 2016-07-19 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9970394

## Citation

> US National Institutes of Health, RePORTER application 9970394, Gene Expression Analysis Core (5P01AI124337-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/9970394. Licensed CC0.

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