# Small viral RNAs as determinants of influenza A virus pathogenesis

> **NIH NIH R01** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $423,750

## Abstract

With just ten major proteins, influenza A virus (IAV) must gain entry to both cell and nucleus, transcribe and replicate its genome, and then perform the inverse of the entry process in order to egress and spread. To achieve this, the virus must introduce new components that change viral biology as the infection progresses. We believe one major component that orchestrates these changes derives from small virus-encoded RNAs (svRNAs) that engage and modulate the viral RNA dependent RNA polymerase (RdRp). This grant focuses on defining how svRNAs change the function of the viral RdRp during the course of infection. The knowledge gained from these studies will significantly contribute to our understanding of IAV biology and may provide an entirely new direction towards the future development of novel therapeutics.

## Key facts

- **NIH application ID:** 9971106
- **Project number:** 1R01AI145882-01A1
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Benjamin R. tenOever
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $423,750
- **Award type:** 1
- **Project period:** 2020-02-04 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9971106

## Citation

> US National Institutes of Health, RePORTER application 9971106, Small viral RNAs as determinants of influenza A virus pathogenesis (1R01AI145882-01A1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9971106. Licensed CC0.

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