# Role of FBXO45 in Diffuse Large B Cell Lymphoma Pathogenesis

> **NIH NIH R01** · UNIVERSITY OF PENNSYLVANIA · 2020 · $505,411

## Abstract

PROJECT SUMMARY
THE ROLE OF FBXO45 IN DIFFUSE LARGE B-CELL LYMPHOMA PATHOGENESIS
Diffuse large B-cell lymphoma (DLBCL) is an aggressive lymphoma and represents the
most common form of malignant lymphoma in the western hemisphere. The biologic events
underlying the pathogenesis of DLBCL are not completely understood. We have recently
identified functional inactivation of FBXO45, an E3 ubiquitin ligase in DLBCL. In this
application, we will utilize transgenic mouse models to explore the biological roles for
FBXO45 in B-cell differentiation and lymphomagenesis. Further, we will employ
biochemical and molecular biology techniques to better understand the role FBXO45 in the
pathogenesis of DLBCL. Accordingly, we propose in the first aim of this application to utilize
newly created transgenic mouse models to functionally interrogate the role of FBXO45 in B-
cell development and lymphomagenesis. In the second aim, we will identify the global
cellular substrates of FBXO45 in B cell contexts. These studies will establish the role of
FBXO45 in the pathogenesis of DLBCL and establish the mechanisms by which its
deregulation contributes to DLBCL.

## Key facts

- **NIH application ID:** 9971477
- **Project number:** 5R01CA231021-02
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** KOJO S. J. ELENITOBA-JOHNSON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $505,411
- **Award type:** 5
- **Project period:** 2019-07-03 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9971477

## Citation

> US National Institutes of Health, RePORTER application 9971477, Role of FBXO45 in Diffuse Large B Cell Lymphoma Pathogenesis (5R01CA231021-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9971477. Licensed CC0.

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