# Microbiome Function in Atopic Dermatitis

> **NIH NIH U01** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $472,500

## Abstract

Summary/Abstract
 Atopic dermatitis (AD) is a common inflammatory skin disease. Recent observations strongly suggest
that the abnormal microbiome present on the skin of subjects with AD is a major factor that influences the
severity and chronic nature of this disorder. In particular, Staphylococcus aureus promotes epidermal barrier
dysfunction and exacerbates the local and systemic immune response. In healthy subjects, beneficial
members of the skin microbiome act to limit the growth of Staphylococcus aureus but these beneficial bacterial
strains are missing on adults with AD. This project seeks to understand why adults with AD lack beneficial
bacterial strains by study of the survival of a prototype strain of Staphylococcus hominis on AD skin.
Interventions to improve its survival will be tested, and application in the pediatric AD population will be
evaluated. Overall, successful completion of the proposed aims of this ADRN Clinical Research Center will
advance understanding of AD and provide essential information to permit development of an innovative new
therapeutic approach based on targeted microbiome therapy.

## Key facts

- **NIH application ID:** 9972306
- **Project number:** 1U01AI152038-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Richard L Gallo
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $472,500
- **Award type:** 1
- **Project period:** 2020-05-01 → 2027-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972306

## Citation

> US National Institutes of Health, RePORTER application 9972306, Microbiome Function in Atopic Dermatitis (1U01AI152038-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9972306. Licensed CC0.

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