# Mouse Metabolic Phenotyping Center (MMPC) at UC Davis

> **NIH NIH U2C** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $1,073,127

## Abstract

MOUSE METABOLIC PHENOTYPING CENTER (MMPC)
 AT THE
 UNIVERSITY OF CALIFORNIA DAVIS (UCD)
ABSTRACT (OVERALL)
This application from the University of California Davis (UCD) seeks base funding to continue operations of its
Mouse Metabolic Phenotyping Center (MMPC) and to expands its gut microbiome research and development
program. The mission of the MMPC-UCD is to advance medical and biological research by providing the
research community with standardized, high quality metabolic and physiologic phenotyping services to validate
and characterize mouse models of diabetes, diabetic complications, obesity and related metabolic disorders.
Our Center is made up of an Administrative Core, an Animal Care Core, and 3 Phenotyping Cores:
Endocrinology and Metabolism Core, Body Composition, Thermoregulation, and Food Intake Behavior Core,
and Complications and Pathology Core. Over the last 5 years, our Center has provided over 27,500 services to
more than 90 clients resulting in 53 publications and program income of over $700,000 that has been
reinvested into the Center to expand and enhance service offerings to clients. In this renewal, our Center
intends to extend and leverage past successes (e.g, bariatric surgery models, microbiome characterization,
analysis of cognitive decline, dietary manipulation of body composition, etc) to continue to focus on clinically
relevant and translatable mouse models. In response to input from the research community, we seek to
provide phenotyping tests that will contribute to new, precision-guided paradigms of disease diagnosis and
therapy. Our Center will offer services to measure physiologic parameters (e.g., cognition and brain
metabolism), assess environmental influences (e.g., host-gut microbiome interactions), and determine the
impact of mitigating factors (e.g., exercise) in client's mice or in mouse models we make for clients. Our overall
goal is to conduct resource-related research, develop and transform technologies into new services, and train
the next generation of researchers using mutant mouse models for the study of diabetes, obesity, and related
metabolic disorders. To achieve these goals, we will 1) provide users with validated and high quality fee-for-
service tests, and to develop important new tests in endocrinology, metabolism, body composition,
thermoregulation, cardiovascular disease, cognition, and exercise; 2) establish a Microbiome Research and
Development Program incorporating projects that uncover the role of the microbiome in host metabolism,
physiology and function, define the impact of the microbiome on disease prevention and pathology, and
explore interactions between the microbiome and its metabolites; and 3) raise awareness among current and
new users of the availability, accessibility, and usefulness of products and services unique to UCD, especially
surgical models, phenotyping procedures, and de novo mouse models, and training in research tools to
investigate mechanisms of metabolic diseas...

## Key facts

- **NIH application ID:** 9972906
- **Project number:** 5U2CDK092993-10
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** KC KENT LLOYD
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,073,127
- **Award type:** 5
- **Project period:** 2011-09-16 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972906

## Citation

> US National Institutes of Health, RePORTER application 9972906, Mouse Metabolic Phenotyping Center (MMPC) at UC Davis (5U2CDK092993-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9972906. Licensed CC0.

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