# Lipid, Lipoprotein, and Glucose Metabolism Core

> **NIH NIH U2C** · UNIVERSITY OF CINCINNATI · 2020 · $316,000

## Abstract

Project Summary (Lipid, Lipoprotein, and Glucose Metabolism Core):
Diabetes is defined by abnormalities in circulating substrates; glucose is obvious, but dyslipidemias also typify
the condition. Central to the impairment of substrate metabolism is beta-cell dysfunction and resistance to
insulin action. There have been significant advances in recent years that have increased our understanding of
normal and abnormal beta-cell function and great progress has been made in elucidating the insulin-signaling
pathway. However, much work remains before translation of these advances to human diabetes. Transgenic
technology holds great promise for making these connections but requires precise and often sophisticated
phenotypic characterization to maximize information gained from appropriate mouse models. It is also clear
that abnormalities in the production and metabolism of lipids and lipoproteins are common in diabetes, that
they interact with the processes governing glucose metabolism, and most importantly, that they are
predisposing factors for cardiovascular disease, the primary cause of death in diabetic humans. To meet the
goals of the UC MMPC as well as the MMPC Consortium, we will continue to focus on the phenotypic analysis
of lipid, lipoprotein, and glucose metabolism in mouse models in order to assist investigators in gaining an
understanding of the effects of specific genetic manipulations and their role in diabetes. Four broad, long-range
goals of the Lipid, Lipoprotein, and Glucose Metabolism Core (Core C) have been established:
Specific Aim 1: To provide current state of the art phenotypic tests that enable the investigators to
characterize the lipid, lipoprotein, and glucose metabolism of their mice.
Specific Aim 2: To advise investigators on the most appropriate tests, and the optimal sequence of tests, to
meet specific goals of phenotypic characterization of their genetically modified mice, or how a physiological
manipulation (e.g. chronic feeding of a high fat diet) modifies the response of the animal.
Specific Aim 3: To train investigators in the performance of specialized procedures established and routinely
practiced in the Core.
Specific Aim 4: To improve current methods and develop new procedures and new approaches to study lipid
and glucose metabolism in mice.

## Key facts

- **NIH application ID:** 9972909
- **Project number:** 5U2CDK059630-20
- **Recipient organization:** UNIVERSITY OF CINCINNATI
- **Principal Investigator:** PATRICK TSO
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $316,000
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972909

## Citation

> US National Institutes of Health, RePORTER application 9972909, Lipid, Lipoprotein, and Glucose Metabolism Core (5U2CDK059630-20). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9972909. Licensed CC0.

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