# Vanderbilt Mouse Metabolic Phenotyping Center

> **NIH NIH U2C** · VANDERBILT UNIVERSITY · 2020 · $1,104,908

## Abstract

The Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC) was founded in 2001 to advance medical and
biological research by providing the scientific community with standardized, high quality phenotyping services
for mouse models of diabetes, diabetic complications, and obesity. The VMMPC consists of five cores. The
Administrative Core provides scientific, financial, and administrative leadership. This Core also oversees
service requests, data management, and tracks mice studied at the VMMPC. The Administrative Core is also
responsible for the VMMPC outreach and educational program. The Animal Health and Welfare Core
evaluates mice submitted to the VMMPC, oversees the health and welfare of the colony, and ensures
compliance with regulatory bodies and MMPC guidelines. Services provided by the Metabolic Regulation Core
(MRC) emphasize methodology to study insulin action, hormone secretion, and metabolism in the conscious,
unstressed mouse. The MRC also has a sophisticated capacity to assess organ or islet function in isolation
and can apply state-of-the-art imaging techniques. The Body Weight Regulation Core has a range of tests to
study determinants of energy balance. These include energy expenditure, feeding behavior, physical activity,
body composition, mitochondrial function, and bariatric surgery procedures. The Analytical Resources Core
(ARC) receives samples generated from VMMPC testing and from experiments conducted outside the
VMMPC. Analyses performed by the ARC are specific to the mouse and are scaled to accommodate small
sample volumes. ARC services range from assessment of hormones, analytes, lipids, lipoproteins, and
atherosclerotic lesions to innovative metabolic flux analysis. The VMMPC exists because of the insight of
leadership at the NIDDK, a generous commitment of space and resources from Vanderbilt University School of
Medicine, and a well-conceived infrastructure. But the main reason the VMMPC works as well as it does is
because of the people that comprise it. The VMMPC exists because of a faculty that is willing to make
technology and guidance available to the scientific community and a staff that is so skilled and committed that
scientists are willing to entrust their mice and valuable samples with them.

## Key facts

- **NIH application ID:** 9972917
- **Project number:** 5U2CDK059637-20
- **Recipient organization:** VANDERBILT UNIVERSITY
- **Principal Investigator:** DAVID H WASSERMAN
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,104,908
- **Award type:** 5
- **Project period:** 2001-07-15 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972917

## Citation

> US National Institutes of Health, RePORTER application 9972917, Vanderbilt Mouse Metabolic Phenotyping Center (5U2CDK059637-20). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9972917. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*