# Core F: Microbiome

> **NIH NIH U2C** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $370,727

## Abstract

Project Summary / Abstract – Core F. Microbiome Core
The Microbiome Core will provide analytical tools to investigators to permit determination of the
structure of the microbiome in mouse models of disease. In addition, the Microbiome Core will
provide assistance in the cultivation of microbes that will permit hypothesis testing in murine models
including the germfree animals that are available in the Animal Phenotyping Core. In addition to
providing instrumental infrastructure, the Core staff will provide consultation and collaboration to
apply microbiome analysis in mouse models of disease. The Microbiome Core will optimize efficiency
and cost-effectiveness by providing these services to investigators through a central laboratory. This
avoids the need for individual investigators to purchase and maintain high price instrumentation in
their own laboratories and avoids the high cost of commercial analytical services. In the past 6 years
we have standardized and implemented several analytical techniques for the analysis of microbial
communities in a culture-independent manner, leveraging advances in high through nucleic acid
sequencing. We are particularly interested in addressing three areas of need: first, applying culture-
independent techniques to study the structure and dynamics of complex microbial communities;
second, utilizing advanced techniques in microbial cultivation to permit hypothesis testing and
understanding the role of bacterial metabolism; and three, providing training for graduate students
and postdoctoral fellows with an interest in utilizing microbiome analysis in their research. By
centralizing and standardizing procedures, the Core provides a common set of analytical tools that
will lead to a unified understanding of molecular mechanisms by which microbes and communities of
microbes can contribute to health and disease.

## Key facts

- **NIH application ID:** 9972920
- **Project number:** 5U2CDK110768-05
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** VINCENT B YOUNG
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $370,727
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972920

## Citation

> US National Institutes of Health, RePORTER application 9972920, Core F: Microbiome (5U2CDK110768-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9972920. Licensed CC0.

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