# UMass Mouse Metabolic Phenotyping Center - Animal Core

> **NIH NIH U2C** · UNIV OF MASSACHUSETTS MED SCH WORCESTER · 2020 · $83,750

## Abstract

Project Summary - Abstract 
Precise phenotyping depends significantly on the quality of animal subjects. Stable housing and husbandry 
minimize the influence of exogenous factors that could distort phenotyping results. Additionally, mice submitted 
to the UMass MMPC share space with cohorts from microbiologically diverse sources. They, as well as mice 
housed in resident colonies, must be protected against potential cross-infection by adventitious agents. The 
Animal Core operates under the supervision of Dr. Jerald Silverman as the Core Director, who oversees the 
animal care facility of UMass Medical School. The Humanized Mouse Cell Transplantation and Assessment 
sub-Core is directed by Dr. Dale Greiner who will offer the humanized mice and elegant techniques to assess in 
vivo function of transplanted human islets and stem cell-derived β-cells in immunodeficient mice. The sub-Core 
will perform standardized assessment procedures that will provide quantifiable metrics for the transplanted 
human islets or stem cell-derived β-cells. The Animal Core provides facilities and services relevant to these 
priorities under the following specific aims: (1) to provide stable, biocontainment housing, husbandry and health 
care for mice (2) to provide a dedicated animal facility for housing (AS2-1043 and 1042) and on-site phenotyping 
procedures (AS2-1043A) with additional phenotyping instruments, (3) to assess the microbiological profile of 
each cohort and provides the Center Director with interpretation and advice regarding the results, and (4) to 
provide to the users of the phenotyping service, at the discretion of the Center Director, results and advice on 
the health status of submitted mice. The goal of the Animal Core is to support the operation of UMass MMPC 
with issues pertinent to animal care and quality of phenotyping mice.

## Key facts

- **NIH application ID:** 9972926
- **Project number:** 5U2CDK093000-10
- **Recipient organization:** UNIV OF MASSACHUSETTS MED SCH WORCESTER
- **Principal Investigator:** GEORGE J DEMARCO
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $83,750
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972926

## Citation

> US National Institutes of Health, RePORTER application 9972926, UMass Mouse Metabolic Phenotyping Center - Animal Core (5U2CDK093000-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9972926. Licensed CC0.

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