# Endocrinology and Metabolism Core

> **NIH NIH U2C** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $173,396

## Abstract

CORE C: ENDOCRINOLOGY AND METABOLISM CORE
ABSTRACT (CORE C)
The main mission of the Endocrinology and Metabolism Core is to provide phenotyping services for the
assessment of endocrine function and metabolic pathways in mouse models of obesity, diabetes, and related
diseases. A major objective of the Endocrinology and Metabolism Core is to provide the expertise, technical
resources, and instrumentation necessary to characterize perturbations in endocrine systems and metabolism
in murine models useful for understanding obesity, diabetes, its complications, and related metabolic disorders,
including NAFLD. The Core will conduct in vitro metabolic procedures (e.g., insulin secretion and adipocyte
metabolism) and perform assays and data interpretation for in vivo metabolic function tests performed by the
Animal Care Core, including IV, IP and oral glucose tolerance tests and insulin tolerance tests for insulin
sensitivity, insulin secretion and glucose disposal. In addition, the Core will offer an extensive list of quality
controlled assays of metabolic substrates, endocrine hormones, and indices of renal function, assessments of
insulin signaling pathways, inflammation and endoplasmic reticulum stress in metabolically important tissues
such as liver, muscle, adipose, pancreas, as well as state-of-the-art metabolomic analysis and interpretation.
Metabolomic assays including complex lipids, phospholipids, bile acids, and biogenic amines. The Core will
also cooperate and coordinate with other Centers in the MMPC Consortium, such as the Bariatric Surgery
Working Group. In addition, the Core will develop and refine new technologies that can be applied to the study
of endocrine function and metabolism in mouse models of obesity and diabetes. For the upcoming project
period, these include continuous glucose monitoring (CGM) and the miniaturization of metabolomic analyses
for the small samples from mice. The team, made up of Drs'. Havel, Haj, Fiehn and Huising, includes
interdisciplinary expertise in the physiology and pathophysiology of obesity and diabetes, animal models of
metabolic diseases, nutrition, biochemistry and molecular biology, immunohistochemistry and imaging, and in
performing and interpreting advanced targeted metabolomics and lipidomic analyses. This team, along with
James Graham, Staff Research Associate in Dr. Havel's laboratory with over 15 years of experience managing
animal studies and assay services, will ensure smooth functioning of the Core, its interactions with other Cores
in our Center and with the MMPC Consortium, Thus, the Endocrinology and Metabolism Core will provide
valuable services to the users of the MMPC-UCD as well as advancing research and providing new tools for
characterizing endocrine and metabolic pathways in mouse models of diabetes and obesity and related
metabolic diseases.

## Key facts

- **NIH application ID:** 9972933
- **Project number:** 5U2CDK092993-10
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** PETER J HAVEL
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $173,396
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9972933

## Citation

> US National Institutes of Health, RePORTER application 9972933, Endocrinology and Metabolism Core (5U2CDK092993-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9972933. Licensed CC0.

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