# Alzheimer's Disease Core Center - Imaging Core

> **NIH NIH P30** · NORTHWESTERN UNIVERSITY · 2020 · $694,340

## Abstract

ABSTRACT:
The purpose of this application is to establish an Imaging Core for the Northwestern Alzheimer’s Disease Center (ADC)
to enhance research activities on aging and dementia within and outside of Northwestern University. The Aims of this
proposal are to: 1) Initiate a Imaging Core in our current cycle focusing on the spectrum from healthy cognitive aging to
dementia, including the FTLD-spectrum of disorders using imaging modalities that will yield optimal quantitative
information on brain structure (MP-RAGE), white matter integrity (FLAIR), axonal pathways (dMRI), resting state
hemodynamic fluctuations for establishing functional connectivity (rs-fMRI), blood flow (ASL) as well as amyloid and
tau binding (amyloid-PET, tau-PET). 2) Establish a secure database, automated pipelines for processing imaging files, and
tools for exploring and accessing the data to facilitate data analysis in order to leverage projects of our collaborators and
to contribute to multi-center data repositories such as the National Alzheimer’s Coordinating Center (NACC). 3) Integrate
imaging parameters with clinical and post-mortem information on Clinical Core subjects in a unified database so that
control subjects can be more fully characterized, patient groups have more solid diagnostic information and clinico-
pathologic correlations can be guided by pre-mortem imaging biomarkers.
 Nearly all aspects of the Northwestern ADC will be enhanced by the availability of the Imaging Core. For example,
the diagnostic, anatomical and physiological characterization of Clinical Core subjects who participate in collaborative
studies will be improved and all clinical investigations at the Northwestern ADC will be able to access more sophisticated
tools for correlating imaging markers with behavioral and clinical parameters. The Imaging Core will unburden
researchers using Clinical Core subjects from the need to gather ad hoc imaging data and will add a new dimension to
clinicopathologic investigations of autopsy specimens. Thus, the range of hypotheses that can be addressed by
collaborative projects relying on Northwestern ADC resources will be increased. An additional and consequential benefit
will be to create new training and research opportunities for young investigators and clinicians at the Northwestern ADC.
The imaging data generated by this proposal will also improve the amount of available multimodal data available in
NACC, which will benefit extramural research.

## Key facts

- **NIH application ID:** 9973058
- **Project number:** 5P30AG013854-25
- **Recipient organization:** NORTHWESTERN UNIVERSITY
- **Principal Investigator:** EMILY J ROGALSKI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $694,340
- **Award type:** 5
- **Project period:** — → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9973058

## Citation

> US National Institutes of Health, RePORTER application 9973058, Alzheimer's Disease Core Center - Imaging Core (5P30AG013854-25). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9973058. Licensed CC0.

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