# Discovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide Induced Cardiovascular Dysfunction

> **NIH NIH K08** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $161,796

## Abstract

Project Summary/Abstract
Dr. Jason Rose is resubmitting this application for a Mentored Research Career Development Award entitled
“Discovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide
(CO) Induced Cardiovascular Dysfunction”. Dr. Rose is a pulmonary and critical care physician, and now,
Assistant Professor of Medicine at the University of Pittsburgh seeking additional training in molecular
engineering, mitochondrial biology, animal models of disease, and drug discovery to further develop into an
independent research investigator. His long-term goal is to lead large academic drug design, discovery and
development programs. His short-term training goals, for this proposal, are to: (1) acquire proficiency in the
assessment of cardiovascular pathophysiology in animal models of disease and develop the skillset to become
a primary investigator in studying the role of mitochondrial dysfunction in human disease; (2) gain expertise in
molecular engineering, targeted drug design and drug discovery assay development; and (3) develop the
management skills to become an expert in the early-stage development of new therapeutics. Building on his
recent graduation from the Tepper School of Business MBA program, he will supplement his training with didactic
courses in molecular pharmacology, drug discovery and cardiovascular physiology. He has assembled experts
in drug discovery, cardiovascular dynamics, and mitochondrial biology to form a cohesive mentor team and
scientific advisory committee. The proposed work will be conducted within the Division of Pulmonary, Allergy,
and Critical Care at the University of Pittsburgh, which has a strong history of training physician scientists and
provides a superb infrastructure for his research and his path to academic independence.
CO exposure is the leading cause of poisoning in the world and there is no antidote to CO. Current interventions
have limited effectiveness: new therapies are needed. The central objective of this proposal is to further identify
and develop an antidotal therapy for CO poisoning. Aim 1 will focus on establishing the mechanisms of CO-
induced cardiovascular toxicity: investigating CO-induced mitochondrial inhibition and measuring hemodynamics
in a severe CO poisoning mouse model. Aim 2 will test the efficacy and safety of recombinant neuroglobin to
reverse the molecular and cardiac dysfunction caused by CO toxicity. Aim 3 will seek to identify novel heme
containing molecules as CO scavengers, using a new manufacturing process and discovery assays. Although
this proposal is ambitious, Dr. Rose has now completed his MBA degree during his intense clinical and research
training demonstrating his ability to multitask in the academic environment. The combination of (1) formal training
in cardiovascular physiology, innovation and molecular pharmacology; (2) novel research experience that
includes disease modeling, drug development and discovery elements;...

## Key facts

- **NIH application ID:** 9973110
- **Project number:** 5K08HL136857-03
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Jason J Rose
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $161,796
- **Award type:** 5
- **Project period:** 2018-07-01 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9973110

## Citation

> US National Institutes of Health, RePORTER application 9973110, Discovering and Developing Recombinant Molecular Scavenging Agents for the Treatment of Carbon Monoxide Induced Cardiovascular Dysfunction (5K08HL136857-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9973110. Licensed CC0.

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