# Core B: Genomics Statistical and Informatics Core

> **NIH NIH U19** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $308,241

## Abstract

Abstract/Summary
This U19 application “Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory
Disease” proposes to generate multiple forms of genomic and clinical trials data, including detailed cross-
sectional and time-course multicellular expression data, and cross-over clinical trials outcome data. The
Genomics, Statistical and Informatics Core (GSIC) will support these efforts by coordinating and conducting
the expression profiling, the data pre-processing, and the bioinformatic and statistical analyses proposed
across the three U19 projects. Based at the laboratories of the Channing Division of Network Medicine, the
GSIC will be staffed by a team of investigators with diverse expertise in the areas of clinical and genetic and
genomic epidemiology of allergic airways disease, clinical trials analysis, and statistical and bioinformatics
analysis of genomic data, including network-based approaches. The GSIC is supported by an established
infrastructure that includes (i) a molecular genetics laboratory specialized in high-throughput genomic data
generation and has more than 20 years experience of large cohort sample collection; (ii) hardware and
software infrastructure for supporting all informatic services, for integrating novel analytic pipelines, and for
storing hundreds of terabytes of data; and (iii) a Bioinformatics Group consisting of 10 full time professional
staff responsible for maintaining the informatics core hardware and software infrastructures. For this U19, the
GSIC will (i) generate the gene expression datasets for Projects 1 and 2; (ii) facilitate streamlined QC
assessment, standardized data preprocessing and normalization, of all experimental data with generation of
formatted reports; (iii) integrate disparate data sources into merged working environments, with relevant
annotation & metadata; (iv) perform all statistical and bioinformatics analysis; and (v) archive all experimental
data and results on a firewall and password protected internal network. By centralization and standardization of
data from across all three projects, the GSIC will serve to promote cross-project integration and synergism by
enabling efficient sharing of data across the 3 projects and ultimately help catalyze new discovery regarding
the pathobiology of Aspirin Exacerbated Respiratory Disease.

## Key facts

- **NIH application ID:** 9973139
- **Project number:** 5U19AI095219-10
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Benjamin Alexander Raby
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $308,241
- **Award type:** 5
- **Project period:** — → 2021-07-22

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9973139

## Citation

> US National Institutes of Health, RePORTER application 9973139, Core B: Genomics Statistical and Informatics Core (5U19AI095219-10). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/9973139. Licensed CC0.

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