# Scientific and Administrative Management Core

> **NIH NIH U42** · CORIELL INSTITUTE FOR MEDICAL RESEARCH · 2020 · $361,504

## Abstract

The NIGMS Human Genetic Cell Repository
U42 Application
FOA No.: RFA-GM-19-002
Project Summary/Abstract
Coriell Institute for Medical Research (Coriell) proposes to maintain and expand the NIGMS
Human Genetic Cell Repository (HGCR). The NIGMS HGCR, established in 1972 at Coriell by
the National Institute of General Medical Sciences (NIGMS), provides a readily accessible,
centralized resource for biospecimens from individuals with inherited disorders, chromosomal
abnormalities, apparently healthy individuals, and individuals of diverse geographic origins for
use in biomedical research. The primary goal of the NIGMS HGCR is to stimulate and facilitate
biomedical research, teaching, and the diagnosis and prevention of human genetic diseases by
establishing and maintaining a repository of high quality, uncontaminated, well characterized,
and clinically well-documented cell lines and DNA and making these resources available to
investigators throughout the U.S. and abroad. The NIGMS HGCR mission is in line with the
NIGMS mission, which is “to support research that increases understanding of life processes
and lays the foundation for advances in disease diagnosis, treatment and prevention”. The
NIGMS HGCR’s activities, all governed by high standards of quality, will include (1) collection,
establishment, characterization, maintenance, and distribution of cell lines, (2) preparation,
storage and distribution of DNA from cell lines, (3) the development and offering of special
genetic services and biomaterials in response to customer requests, (4) maintenance of a
comprehensive database and online catalog, and (5) publicizing the NIGMS HGCR’s
collections. The NIGMS HGCR will maintain, grow and distribute the current collection of
approximately 11,800 unique cell lines, 6,400 DNA samples, and 54 human iPSC lines in its
online catalog, as well as newly acquired resources. The NIGMS HGCR will continue to create
human induced pluripotent stem cell (iPSC) lines at Coriell by reprogramming certain NIGMS
HGCR cell lines. Additionally, Coriell is committed to integrating state-of-the-art technologies
into its activities and will continue to offer a wide range of cutting edge services that enhance
the utility of the HGCR collection to the genetic research community.

## Key facts

- **NIH application ID:** 9973344
- **Project number:** 2U42GM115336-06
- **Recipient organization:** CORIELL INSTITUTE FOR MEDICAL RESEARCH
- **Principal Investigator:** Deborah Requesens
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $361,504
- **Award type:** 2
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9973344

## Citation

> US National Institutes of Health, RePORTER application 9973344, Scientific and Administrative Management Core (2U42GM115336-06). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/9973344. Licensed CC0.

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