# Continued Development and Maintenance of the UltraScan Software

> **NIH NIH R01** · UNIVERSITY OF MONTANA · 2020 · $293,074

## Abstract

Project Summary/Abstract
We propose to continue development and support for the UltraScan-III (US3) software suite and develop new
code and methods to address challenging biomedical research questions that can be solved with the latest
instruments available for analytical ultracentrifugation and at beamlines for small-angle X-ray and neutron
scattering experiments (SAXS/SANS) experiments. UltraScan is a comprehensive toolkit for the analysis of
data from hydrodynamic experiments and simulations. Such experiments include analytical ultracentrifugation,
SAXS/SANS, as well as bead modeling simulations. Support for this project will assure continued availability of
a mature multi-platform analysis suite with important and unique capabilities not found in any other software
packages. Chief among them are tight integration of supercomputing capabilities, LIMS support for
collaboration, and specialized analysis routines. US3 enjoys widespread use in the AUC and SAXS/SANS
communities, and offers the most robust optimization and simulation algorithms available, resulting in
unmatched detail. UltraScan provides the highest throughput, a flexible, modern GUI, and a comprehensive list
of analysis routines. Proposed developments include automated data acquisition and analysis workflows,
improvements in the fitting of floating data, improved two-dimensional grids, support for density distribution
analysis critical for the accurate characterization and quantification of viral vectors, lipid nanoparticles loaded
with cancer drugs or nucleic acids, and other vectors used for the delivery of medicines or CRISPR technology.

## Key facts

- **NIH application ID:** 9973635
- **Project number:** 2R01GM120600-05
- **Recipient organization:** UNIVERSITY OF MONTANA
- **Principal Investigator:** Emre H. Brookes
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $293,074
- **Award type:** 2
- **Project period:** 2016-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9973635

## Citation

> US National Institutes of Health, RePORTER application 9973635, Continued Development and Maintenance of the UltraScan Software (2R01GM120600-05). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9973635. Licensed CC0.

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