# Influence of Prenatal and Early Childhood Home-Visiting by Nurses on Development of Chronic Disease: 29-year Follow-Up of a Randomized Clinical Trial

> **NIH NIH R01** · UNIVERSITY OF COLORADO DENVER · 2020 · $1,814,215

## Abstract

Project Summary
 This study consists of a 30-year follow-up of participants (N=742) in a randomized clinical trial of the
Nurse-Family Partnership (NFP), a program of prenatal and infant/toddler home-visiting by nurses for low-income
women with no previous live births, focusing on emergent chronic disease in mothers and first-born offspring.
Previous assessments were conducted at registration, at the 36th week of gestation, and at the child’s 6th month
and years 1, 2, 4.5, 6, 9, 12, and 18. NFP nurses are charged with improving: 1) pregnancy outcomes; 2)
children’s health and development; and 3) women’s health and economic self-sufficiency. They do this by
promoting women’s health behaviors, care of their child, planning subsequent pregnancies, completing their
educations and finding work. Nurses explicitly promote women’s self-efficacy/mastery in managing challenges,
foster informal social support (including involving fathers), and link families with health and human services. We
propose to continue surveillance of health outcomes among mothers and offspring enrolled in this second NFP
trial, which focused on very low-income, primarily African American (89%) women and their offspring. Eighty-
five percent of the randomized mothers and offspring were assessed at the most recent 18-year follow-up.
 NFP effects have been found on a range of maternal outcomes through child age 18, including
Pregnancy-Induced Hypertension (PIH), closely spaced subsequent pregnancies, marriage, sense of mastery,
use of government benefits; and among mothers of females, reduced BP and self-reported kidney and heart
problems. Nurse-visited offspring, through age 18, had lower rates of preventable mortality; among those born
to mothers with limited coping capacity, lower rates of low birthweight and compromised cognitive functioning,
receipt of Social Security Disability; and, among females, lower rates of obesity.
 At the 30-year follow-up, we expect to complete assessments on at least 80% of those randomized, 594
mothers and offspring. Findings from earlier follow-ups have led to our general hypothesis that, over the
life-course, the intervention will lead to reductions in the emergence of cardio-vascular disease, chronic
kidney disease, type-2 diabetes, and premature mortality among both mothers and their first-born
offspring. We will a) conduct anthropometric assessments; b) draw blood to measure cardio-metabolic and
immune-inflammatory factors; c) collect random urines to measure the microalbumin/creatinine ratio and
cotinine; d) evaluate arterial stiffness using SphygmoCor and a standard peripheral BP instrument; e) conduct
interviews to assess history of diagnoses, medications, menopause, hospitalizations, disability, sedentary and
physical activity, sleep, diet, use of substances, depression, anxiety, sense of mastery, chronic pain, duration
and quality of partnered relationships, education, work, and incarceration; f) review hospitalization records; and
g) class...

## Key facts

- **NIH application ID:** 9974102
- **Project number:** 1R01HL148183-01A1
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Dana Dabelea
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,814,215
- **Award type:** 1
- **Project period:** 2020-06-22 → 2024-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9974102

## Citation

> US National Institutes of Health, RePORTER application 9974102, Influence of Prenatal and Early Childhood Home-Visiting by Nurses on Development of Chronic Disease: 29-year Follow-Up of a Randomized Clinical Trial (1R01HL148183-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9974102. Licensed CC0.

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