# ADMINISTRATIVE CORE

> **NIH NIH P01** · UT SOUTHWESTERN MEDICAL CENTER · 2020 · $99,007

## Abstract

Project Summary/Abstract (Admin Core) 
We have established an innovative Program entitled “Developmental Mechanisms of Human Idiopathic 
Scoliosis”. This program combines unbiased gene discovery in humans, modeling and gene discovery in 
zebrafish, and genomic analysis of gene regulatory sequences that will define the underlying causes of 
adolescent idiopathic scoliosis (AIS), the most common musculoskeletal disorder in children. Three research 
groups are leading these efforts. Project 1 “Human” focuses on AIS gene discovery and is led by Carol A. 
Wise, PD, PI, University of Texas Southwestern Medical Center and Texas Scottish Rite Hospital for Children. 
Project 2 “Zebrafish” is led by Lila Solnica-Krezel, Washington University School of Medicine St. Louis. 
Project 3 “Genomics” is led by Nadav Ahituv, University of California San Francisco. The Administrative Core 
will aid activities of the Program, which is already a working collaborative, and will be ultimately responsible for 
its execution and productivity. The Core will facilitate organization, communication, data flow, compliance, and 
productivity between the research groups. Specific responsibilities of the Core will be to ensure effective and 
frequent communication between component groups of the project, to establish and communicate with an 
Advisory Committee, to respond to advice from the committee, to ensure that funding is disbursed 
appropriately, to maintain compliance and oversee quality control, and to support high productivity. The 
Program Director Dr. Wise and an administrative assistant will oversee the administration of the Program. A 
primary activity of the Administrative Core will be to coordinate frequent, structured meetings between groups 
and the Advisory Committee as a forum for regular updates, to promote the exchange of ideas and data, and 
to keep the program on track by monitoring adherence to established timelines. The Core will organize an 
annual, dedicated face-to-face meeting of the Program components and Advisory Committee. The core will 
also coordinate meetings at conferences, notably the NICHD Birth Defects workshop and other professional 
meetings. Importantly, the Administrative core will summarize key conclusions and critical follow-up steps that 
emerge from all meetings, whether electronic or in person, for the Program. Otherwise the Administrative Core 
will be responsible for regularly monitoring budgets, compliance with ethical guidelines, compliance with 
institutional and federal requirements (e.g. institutional review boards, institutional animal care and use 
committees), and compliance with data-sharing policies. Finally, the Core will facilitate the preparation and 
submission of manuscripts, ensuring fairness and consistency with NIH public access policies. In these ways 
the Core will promote synergistic interaction within the Program and hasten the goal to decipher the 
pathogenesis of AIS. 
1

## Key facts

- **NIH application ID:** 9974360
- **Project number:** 5P01HD084387-05
- **Recipient organization:** UT SOUTHWESTERN MEDICAL CENTER
- **Principal Investigator:** CAROL A WISE
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $99,007
- **Award type:** 5
- **Project period:** — → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9974360

## Citation

> US National Institutes of Health, RePORTER application 9974360, ADMINISTRATIVE CORE (5P01HD084387-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9974360. Licensed CC0.

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