# Preclinical Oxygen Imager to Model Efficient Cancer Treatment

> **NIH NIH R44** · O2M TECHNOLOGIES, LLC · 2020 · $831,635

## Abstract

Abstract
This SBIR Phase II proposal is designed to advance the progress made during the SBIR Phase I project “Robust
Small Animal Oxygen Imager to Model Enhanced Cancer Treatment”. During Phase I, we have developed a
prototype of robust oxygen imager, JIVA-25, for preclinical cancer biology and radiation therapy research. In
the current proposal, we plan improvements in hardware, software, and image acquisition methodology that
will lead to reduced instrument weight, better instrument performance, and higher resolution oxygen maps. In
addition, we will evaluate the JIVA-25 performance with cancer research animal studies that use radiation
therapy and drug application.
JIVA-25 is a 25 mT oxygen imager with small footprint based on the principles of electron paramagnetic
resonance oxygen imaging. JIVA-25 can provide oxygen maps in tissues with 1 mm spatial resolution, 1 torr
oxygen resolution and 1-10 min temporal resolution. No other competing method can provide accurate
noninvasive pO2 maps with such precision. In tumor, accurate real-time pO2 maps will lead to oxygen guided
radiation therapy (OGRT). OGRT is expected to reduce the delivered high radiation dose volume by lowering
the dose to well-oxygenated tumor tissues. This will preserve the structure and integrity of irradiated tissues
and reduce radiation side effects. The absence of preclinical (animal) oxygen imaging data is the major
impediment in the development of evidence base for OGRT translation into clinics. The availability of oxygen
maps in preclinical settings is also expected to lead to advanced drug and radiation therapies. Providing the
research community with JIVA-25 instrument is the first step in achieving these goals.

## Key facts

- **NIH application ID:** 9974497
- **Project number:** 5R44CA224840-03
- **Recipient organization:** O2M TECHNOLOGIES, LLC
- **Principal Investigator:** Mrignayani Kotecha
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $831,635
- **Award type:** 5
- **Project period:** 2019-07-08 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9974497

## Citation

> US National Institutes of Health, RePORTER application 9974497, Preclinical Oxygen Imager to Model Efficient Cancer Treatment (5R44CA224840-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9974497. Licensed CC0.

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