# Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Network Clinical Center (Hub)

> **NIH NIH U24** · UNIVERSITY OF MINNESOTA · 2020 · $135,814

## Abstract

The ability to effectively study and develop innovative treatments for acute critically ill or injured
patients has been challenging. Many of these devastating conditions occur infrequently ,which
lessens the ability to enroll large number of patients into clinical trials. Many render the patient
incapacitated, and identification of their legally authorized representatives to provide meaningful
prospective informed consent for participation may not be possible. Yet, the current therapies for
many of these devastating conditions are often understudied or unsatisfactory. With these issues
in mind and because of the sincere desire to improve acute care of critically ill and injured
patients, the Strategies to Innovate Emergency Care Clinical Trials network ( SIREN ) has been
created. This proposal is for the establishment of a SIREN Hub at the Department of Emergency
Medicine at the University of Minnesota (UMn SIREN). The University of Minnesota is uniquely
qualified to serve as the SIREN Hub , with academic depth in various domains of acute critical
care, pre-hospital and emergency research. The Hub leadership is experienced in the spectrum of
acute care clinical research, pre-hospital research, the use of Exception from Informed Consent
for acute critical care clinical trials. The various specialties needed to collaborate for successful
implementation of SIREN are aligned with collaborative arrangements beyond traditional
departments.
The Specific Aims of Year One are;
1. Create the UMn SIREN hub infrastructure using lessons learned from the Minnesota NETT
Hub and UMn Stroke Net Regional Coordinating Center.
2. Prepare and support Spokes and aligned Emergency Medical Service ( EMS) agencies for the
launching of SIREN clinical trials.
3. Determine best methods of monitoring Spoke performance and develop quality assurance
processes to ensure compliance with all regulatory requirements for the conduct of clinical trials.
4. Recruit , engage and maintain involvement of pre-hospital, emergency and acute care
clinicians; Spoke leadership and institutions; and health care systems and EMS in SIREN
activities and SIREN clinical trials.

## Key facts

- **NIH application ID:** 9974593
- **Project number:** 5U24NS100649-04
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** James R. Miner
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $135,814
- **Award type:** 5
- **Project period:** 2017-07-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9974593

## Citation

> US National Institutes of Health, RePORTER application 9974593, Network for Emergency Care Clinical Trials: Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) - Network Clinical Center (Hub) (5U24NS100649-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9974593. Licensed CC0.

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