# RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core

> **NIH NIH U19** · VANDERBILT UNIVERSITY MEDICAL CENTER · 2020 · $506,766

## Abstract

ABSTRACT 
CORE B: RSV to Asthma Cooperative Clinical Ascertainment, Biospecimen, and Data Management 
Research Core 
Core B is designed as the clinical ascertainment and data management core. The INSPIRE (Infant 
Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure) birth cohort successfully enrolled 
over 1900 term healthy infants and will have followed them to approximately 4 years of age during the first 
funding cycle. This core extends the longitudinal follow-up to age 6-8 years at which time the cumulative 
incidence of asthma will be defined, and include physiologic testing as well as additional biospecimens, thus 
providing resources directly to Projects 1 and 2. The core will coordinate the data to address the fundamental 
questions about the causal role of asthmagenic strains of RSV on childhood asthma through scientific projects 
that focus on interactive pathways of the viral strain and host on asthma development (Project 1), and the 
mechanisms through which specific RSV strains cause asthma (Project 2). Our specific aims are to 1) 
facilitate longitudinal follow-up of the INSPIRE cohort, with biospecimen and data management for Projects 1 
and 2; and 2) integrate clinical, physiological, immunologic, microbiome and viral sequencing data from 
collaborating sites and provide analytic support to address research questions across projects. This core 
assembles a complementary research team of epidemiologists, virologists, immunologists, biostatisticians, and 
research personnel experienced in cohort retention, biospecimen acquisition and processing, and data 
management. As bronchiolitis and asthma are the most common, serious, acute and chronic conditions of 
infancy and childhood, respectively, and are diseases that disproportionately burden vulnerable populations, 
this core and supported projects will have major, long-lasting impact by improving our understanding of RSV- 
mediated asthma.

## Key facts

- **NIH application ID:** 9975085
- **Project number:** 5U19AI095227-11
- **Recipient organization:** VANDERBILT UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Tina V Hartert
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $506,766
- **Award type:** 5
- **Project period:** 2011-08-01 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9975085

## Citation

> US National Institutes of Health, RePORTER application 9975085, RSV to Asthma Cooperative Clinical Ascertainment and Biospecimen Research Core (5U19AI095227-11). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9975085. Licensed CC0.

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