# Evaluating the Impact of Guidelines on Physician Prescription Practices in Chronic Kidney Disease

> **NIH NIH F32** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $73,650

## Abstract

ABSTRACT
Cardiovascular disease is the leading cause of morbidity and mortality among individuals with chronic kidney
disease (CKD). Despite evidence and clinical practice guidelines supporting the use of statins for
cardiovascular risk reduction in non-dialysis requiring chronic kidney disease, prevalence of statin prescription
among individuals with CKD remains low. Strategies to increase statin use represent an important opportunity
to improve cardiovascular outcomes for this population. Reasons underlying the current low rates of statin use
remain unclear, thus elucidating these reasons will be important for informing the design of successful
implementation strategies.
The specific aims of this proposal are intended to examine different factors that influence rates of statin
prescription among individuals with CKD. Aim 1 will assess the impact of changes in clinical practice guidelines
by examining temporal trends in statin use among individuals with CKD using a nationally representative
database. Aims 2 and 3 will examine more granular provider-level factors that may influence statin prescription
(i.e., the contribution of nephrology care to cardiovascular risk management, primary care provider (PCP)
knowledge of preventive cardiovascular care guidelines, PCP perception of cardiovascular risk in CKD
patients) and correlate them with individual practice behaviors, using data from the San Francisco Health
Network, a local public health system that disproportionately cares for individuals of low socioeconomic status.
The study design will involve cross-sectional analyses of both a large national dataset (the National Health and
Nutrition Examination Survey; NHANES) for Aim 1 and a local dataset from the electronic health record of one
health delivery system (San Francisco Health Network) for Aims 2 and 3. Aim 3 will also involve a survey of
local primary care providers to assess awareness of guidelines and perceptions of cardiovascular risk pertinent
to CKD patients.

## Key facts

- **NIH application ID:** 9975628
- **Project number:** 5F32DK122629-02
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Chi Chu
- **Activity code:** F32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $73,650
- **Award type:** 5
- **Project period:** 2019-07-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9975628

## Citation

> US National Institutes of Health, RePORTER application 9975628, Evaluating the Impact of Guidelines on Physician Prescription Practices in Chronic Kidney Disease (5F32DK122629-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9975628. Licensed CC0.

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