# Computation and Biostatistics Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2020 · $230,150

## Abstract

Computational Core: Biostatistical Analysis and Network Modeling
Core Co-Directors: David Gjertson PhD and Alexander Hoffmann PhD
SUMMARY
This application proposes three research Projects and three Cores for shared resources led by investigators at
the University of California Los Angeles (UCLA), centered around the theme of investigating innate-adaptive
immunoregulation in liver transplant ischemia/reperfusion Injury (IRI). Projects I and II focus on modulation of
IRI immune responses following hepatic grafting in syngeneic and allogeneic murine models, respectively;
whereas, Project III concentrates on elucidating the role of IRI on immunoregulation following human OLT.
Core C provides data management, biostatistical and computational expertise required for the proper analysis
and network modeling of data generated by Projects. Statistical and mechanistic modeling will allow the
integration of diverse datasets to develop predictions, and may generate new findings and insights by comparing
the datasets from the three types of liver transplants.
Services will be provided in the following areas:
• Data quality control, monitoring and management.
• A central infrastructure for data preprocessing of high throughput molecular data.
• Biostatistical design, statistical monitoring of studies to ensure interpretability of results.
• Statistical analysis and interpretation of diverse datasets.
• Development of biostatistical methodology for statistical problems in these projects.
• Modeling molecular networks to interpret transcriptome data and provide knowledge-based dimensionality
reduction
• Modeling the immune-cell dynamics to interpret immune-phenotyping datasets and integrate molecular and
 cellular scale data and analyses.
• Assistance with manuscript preparation.

## Key facts

- **NIH application ID:** 9975696
- **Project number:** 5P01AI120944-04
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** David Gjertson
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $230,150
- **Award type:** 5
- **Project period:** 2017-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9975696

## Citation

> US National Institutes of Health, RePORTER application 9975696, Computation and Biostatistics Core (5P01AI120944-04). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9975696. Licensed CC0.

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