# CSHL Cancer Center Support Grant

> **NIH NIH P30** · COLD SPRING HARBOR LABORATORY · 2020 · $4,403,952

## Abstract

CSHL Cancer Center – Overall Project Summary/Abstract
The Cold Spring Harbor Laboratory (CSHL) Cancer Center is a premier cancer research center that uses
innovative and collaborative approaches to address some of the most pressing challenges facing cancer
biologists and cancer patients today. In particular, research in CSHL Cancer Center is focused on two primary
problems: improving cancer diagnostics and increasing therapeutic effectiveness.
Researchers in the CSHL Cancer Center are employing cutting edge genetic and genomic approaches to
molecularly characterize cancer. The goals of this research are to both develop new diagnostic tools and to
also define cancer subtypes so that clinicians will be able to select the most effective therapeutic approaches.
CSHL Cancer Center researchers are at the forefront of developing and applying these genomic approaches;
discoveries like single cell sequencing have the power to revolutionize diagnostics and are already
demonstrating tremendous potential in the clinic.
The CSHL Cancer Center is building upon its outstanding foundation in basic discovery science to identify and
develop new therapeutic targets for multiple tumor types. More than ten years ago, the Cancer Center
formalized this strategy with the creation of a “cancer discovery pipeline.” The plan integrated basic cancer
biology, human cancer genetics, high-throughput screening technology, and innovative animal models in an
effort to improve existing treatments for cancer. This pipeline has been tremendously successful. Cancer
Center researchers have discovered new cancer genes, identified potential therapeutic targets, and explored
new drug resistance mechanisms. As this basic research continues, the Cancer Center is aiming to extend the
pipeline even further into translational research. Over the next five years, as part of a Cancer Therapeutics
Initiative, the Cancer Center will bring its basic research discoveries to preclinical and clinical settings.
Funding from the National Cancer Institute provides the CSHL Cancer Center with the organizational and
financial support needed to make a significant impact on cancer diagnosis and treatment. The three research
programs (Gene Regulation & Cell Proliferation; Signal Transduction; Cancer Genetics) provide opportunities
for members to come together, maximizing collaboration and communication. The nine Shared Resources
provide access to technologies, services, and expertise to enhance productivity and promote multidisciplinary
interactions. Essential Developmental Funds enable the Center to remain at the forefront of cancer research.
Together, these elements of the CSHL Cancer Center create an environment that supports the level of
scientific discovery required to make real progress in improving cancer diagnosis and treatment.

## Key facts

- **NIH application ID:** 9975703
- **Project number:** 5P30CA045508-33
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** David A Tuveson
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $4,403,952
- **Award type:** 5
- **Project period:** 1997-08-01 → 2021-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9975703

## Citation

> US National Institutes of Health, RePORTER application 9975703, CSHL Cancer Center Support Grant (5P30CA045508-33). Retrieved via AI Analytics 2026-05-31 from https://api.ai-analytics.org/grant/nih/9975703. Licensed CC0.

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