# Bioinformatics Shared Resource

> **NIH NIH P30** · COLD SPRING HARBOR LABORATORY · 2020 · $318,030

## Abstract

Bioinformatics Shared Resource - Project Summary/Abstract
The Bioinformatics Shared Resource (BSR) provides essential services and technical support for all aspects of
bioinformatics for CSHL Cancer Center members. The pervasive need for Bioinformatics in the genomic era for
all aspects of biological research makes it an essential tool for cancer researchers. Over the past five years, a
total of 21 Cancer Center members (57% of members) used the bioinformatics programming and analysis
services of the BSR, accounting for 93% of its total use. This has contributed to 60 publications over this time
period. The goal of the BSR is to give Cancer Center members access to state-of-the-art bioinformatics
expertise and support. This includes consulting with Cancer Center members to find the best available
bioinformatics software for their particular projects, as well as developing new tools and techniques for Cancer
Center members whose projects push the boundaries of what is currently available. Next-generation
sequencing technology has revolutionized the scientific questions that can be addressed, leading to a pressing
need for both improved statistical analysis tools and standardized analysis protocols. The large volumes of
data created have also necessitated an increased need for both basic and advanced bioinformatics support.
The BSR has taken a proactive role in building the computational infrastructure required to support these large-
scale genomics projects. During the past five years, the BSR developed novel computational tools for
sequencing data analysis, established standard pipelines for sequencing data analysis, built powerful
computational servers to support data analysis for the CSHL cancer community, and trained the students and
postdoctoral scholars at CSHL to use these new computational tools. One major goal is to continually upgrade
and improve these computational support structures to ensure the long-term sustainability of sequencing data
analysis at the CSHL Cancer Center. The second major goal is to contribute computational infrastructure that
remains at the forefront of cancer research. Specifically, during the next five year period, the BSR intends to
develop novel computational tools to address the newest questions at the forefront of cancer research,
including the development of software to support single-cell sequencing studies and to aid in the design of
CRISPR guide RNAs for functional genomics studies.

## Key facts

- **NIH application ID:** 9975715
- **Project number:** 5P30CA045508-33
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** Molly Gale Hammell
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $318,030
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9975715

## Citation

> US National Institutes of Health, RePORTER application 9975715, Bioinformatics Shared Resource (5P30CA045508-33). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9975715. Licensed CC0.

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