# Multi-omic Subtyping of Chronic Obstructive Pulmonary Disease

> **NIH NIH K08** · BRIGHAM AND WOMEN'S HOSPITAL · 2020 · $172,800

## Abstract

PROJECT SUMMARY/ABSTRACT
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality in the United
States. COPD is a highly heterogeneous disease and some COPD therapies are only applied to specific
clinically defined subtypes. With the advent of multiple high-throughput biological assays and machine learning
approaches, data-driven subtypes are increasingly being recognized. We hypothesize that such subtypes exist
in COPD and that they can be identified using an integrative, multi-'omic approach. To accomplish this
goal, we first propose to complement existing RNA and whole genome sequencing data in the well-phenotyped
COPDGene study with peripheral blood microRNA sequencing. We will study the relationship of microRNA to
genetic variation and gene expression in COPD. Next, we will apply a patient-based network similarity method
to these three data types to identify COPD molecular subtypes. Finally, we will associate these subtypes with
important clinical phenotypes and outcomes, and validate these subtypes in an independent subset of
subjects. Our analysis targets a key clinical problem in COPD management, and will allow the mentee to
become an independent investigator, applying bioinformatic and machine learning methods to genomic data in
respiratory diseases.

## Key facts

- **NIH application ID:** 9975882
- **Project number:** 5K08HL136928-04
- **Recipient organization:** BRIGHAM AND WOMEN'S HOSPITAL
- **Principal Investigator:** Brian Daniel Hobbs
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $172,800
- **Award type:** 5
- **Project period:** 2017-07-01 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9975882

## Citation

> US National Institutes of Health, RePORTER application 9975882, Multi-omic Subtyping of Chronic Obstructive Pulmonary Disease (5K08HL136928-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/9975882. Licensed CC0.

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