# Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV

> **NIH NIH K01** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2020 · $128,449

## Abstract

PROJECT SUMMARY/ABSTRACT
 Advancements in therapy have drastically improved life expectancy for people living with HIV and many
individuals are living well into older adulthood. Older adults living with HIV, defined as those who are 50 years
and older, make up almost half of all individuals living with HIV in the US. Although life expectancy has
increased, older adults living with HIV have greater risk for multiple physical, mental, and psychosocial health
burdens compared to uninfected older adults. It is well documented that people living with HIV are at increased
risk for impaired cognition, including cognitive impairment leading to dementia and Alzheimer’s Disease, and
HIV associated neurocognitive disorders (HAND). The consequences of cognitive impairment among this
population have far reaching implications for population and public health. Impaired individuals may lose the
ability to fully engage in activities involved in HIV care, such as adherence to antiretroviral therapies. Impaired
individuals may also lose the ability to fully engage in other health promoting and beneficial behaviors such as
participate in physical and leisure activities, and activate or utilize positive resources like social support,
purpose in life, and financial resources. Taken within a broader life course context, having multiple life
stressors may also negatively impact the ability to engage in health behaviors and resources and influence
cognitive outcomes. However, research has yet to disentangle the impact of cognition on engagement in
healthy behaviors within the context of positive resource utilization in older adults with HIV. A greater
understanding of this is needed given the aging of the population living with HIV and the corresponding public
health burden. The overall goals of the proposed Career Development Award (K01) goals are to investigate the
relationship between cognitive deficits and health promoting behaviors, clarify the moderating role of positive
resources, and to determine the cumulative impact of these interactions on quality of life for older adults
experiencing stress while living with HIV. This will be achieved through the completion of the proposed training
plan, organized under the four content domains of cognition, HIV and aging, biostatistics and longitudinal
research design, and professional development. This training plan was designed with the goal of launching the
PI’s career as an independent investigator with a research program focused on the interplay of cognition,
psychosocial factors, and life stress on health and successful aging in individuals aging with HIV.

## Key facts

- **NIH application ID:** 9976087
- **Project number:** 1K01AG064986-01A1
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Annie Lu Nguyen
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $128,449
- **Award type:** 1
- **Project period:** 2020-04-15 → 2025-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9976087

## Citation

> US National Institutes of Health, RePORTER application 9976087, Cognitive Health, Psychosocial factors, and behaviors relevant to aging successfully with HIV (1K01AG064986-01A1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9976087. Licensed CC0.

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