The Operations Core (OC) supports OAIC investigations of multifactorial geriatric conditions by recruiting and retaining diverse populations of older persons, seeking input from the local community in research planning and dissemination, monitoring participant safety, ensuring regulatory compliance, developing surveys and instruments, designing Information Technology (IT) systems to implement research, collecting and preparing data for statistical analysis, and providing continuity and shared knowledge across projects. The overall goal of the OC (RC1) is to ensure the successful implementation of research focused on multifactorial geriatric conditions. This goal will be accomplished by leading, managing, and coordinating the effective, efficient and innovative use of facilities, data, staff, resources, and space. There is a consistent demand for experienced personnel with the ability to quickly execute aging-focused research and an increasing need for informatics skills and technology to streamline work. The Specific Aims of the OC are: 1) to provide an infrastructure suitable to support Yale OAIC-funded projects and External Projects. This infrastructure includes experienced personnel, staff training modules, standard operating procedures for conducting field studies, and comprehensive clinical research informatics (CRI) services; 2) to collaborate with the REC, PESC, and Biostatistics Core (RC2) to develop specific CRI and field operations systems for Yale OAIC-funded projects and External Projects; and 3) to conduct innovative OC Development Projects that advance the mission of the Yale OAIC. During the current funding cycle (2013-present), the Operations Core was integrally involved in research support of 80 OAIC-funded projects and External Projects, numerous collaborations within Yale, and engagement with several other Pepper Centers. Altogether, these efforts have resulted in 114 peer-reviewed publications and 81 extramurally funded grants (>$145 million total costs) of which 25 involved 18 junior faculty specializing in aging/geriatrics research. During the next funding cycle, the OC will: (1) collaborate on 4 of the 5 proposed REC and PESC projects, 24 of the 29 funded External Projects, and 7 pending projects from grant submissions involving more than $13 million in total costs; (2) substantially expand and enhance the clinical research informatics infrastructure at Yale School of Medicine, in partnership with leaders from each clinical research support center; and (3) lead an innovative Development Project, the Clinical Decision Support System (CDSS) Toolkit, that will make it possible for any research team having access to REDCap to implement a sophisticated, HIPAA-secure CDSS. The CDSS toolkit will support the growth of projects related to the OAIC subtheme of individualized decision making for older persons with multiple chronic conditions.