# Core C: Animal Models Core

> **NIH NIH P50** · UNIVERSITY OF ALABAMA AT BIRMINGHAM · 2020 · $246,319

## Abstract

Project Summary: Core C, Animal Models Core
Current treatments for Parkinson's disease (PD) alleviate the symptoms, but do not prevent the progression of
the disease. Finding novel therapeutic targets to prevent the progression of the disease requires animal model
that recapitulate the features of PD. The α-syn fibril model of Parkinson Disease replicates features of the
disease such as inclusions in the substantia nigra pars compacta, dopamine neuron loss and motor defects.
The goal of the Core C: Animal Models Core is to standardize this models to generate consistent results
across the projects. Animal Models Core will purify and generate low endotoxin recombinant α-syn, generate
fibrils and perform quality control assays such as sedimentation and Thioflavin T assays, dynamic light
scattering and transmission electron microscopy. The Animal Models Core will also perform all of the
stereotactic injections to minimize variability in stereotactic technique. Perfusions, tissue sections and
immunohistological techniques and unbiased stereology will also be performed. Having highly trained
personnel from the Core perform these techniques will produce high quality data and will minimize potential
variability.

## Key facts

- **NIH application ID:** 9976622
- **Project number:** 5P50NS108675-03
- **Recipient organization:** UNIVERSITY OF ALABAMA AT BIRMINGHAM
- **Principal Investigator:** Laura A. Volpicelli-Daley
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $246,319
- **Award type:** 5
- **Project period:** 2018-09-30 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9976622

## Citation

> US National Institutes of Health, RePORTER application 9976622, Core C: Animal Models Core (5P50NS108675-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9976622. Licensed CC0.

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