# Rush Alzheimer's Disease Core Center

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $3,522,718

## Abstract

ABSTRACT - OVERVIEW
The overall goal of the proposed renewal of the Rush Alzheimer’s Disease Core Center (Rush ADCC) is to
continue to support the performance of cutting edge and innovative research on the etiology, pathogenesis,
diagnosis, treatment, and prevention of MCI, AD, and other common dementias, by providing researchers with
a stimulating multi-disciplinary environment, and unique and highly valued clinical and post-mortem data, and
ante- and post-mortem biologic specimens. The Rush ADCC has been in continuous operation since 1991. It
has eight Cores carefully designed to support a variety of timely and important areas of research including
studies: 1) of the transition from normal aging to MCI and to the earliest stages of dementia with substantial
participation by racial and ethnic minorities, 2) linking risk factors to normal aging, incident MCI and incident
AD, and to post-mortem indices of AD and mixed pathologies, 3) that incorporate contemporary high
throughput biochemical and molecular data into clinical-pathologic cohort studies, and 4) that link
neuroimaging and biofluid biomarkers to contemporary biochemical and molecular data, 5) that support drug
discovery pipelines, and 6) that support studies of impaired motor function.
The Administrative Core will provide scientific leadership to the ADCC as a whole. The Clinical Core will collect
UDS and additional data on Blacks without dementia and work to obtain brain autopsy. The Religious Orders
Study (ROS) Core will follow older members of Catholic religious communities who have agreed to annual
evaluation and brain donation at death. The Latino Core will collect the same data as in ROS on older Latinos
without dementia and work to obtain brain autopsy. The Neuropathology Core will process, store, evaluate
and distribute biospecimens obtained by the Clinical, ROS, and Latino Cores. The Outreach and Recruitment
Core will provide a wide range of educational programs to support outreach and recruitment of racial and
ethnic minorities into the Clinical and Latino Cores, and other NIA funded initiatives. The Data Management
and Statistical Core will continue to provide the infrastructure that allows all other Cores to be maximally
successful and impactful, and will provide statistical support to users of ADCC resources especially junior
investigators and trainees. The new Research and Education Component will provide a structured program of
mentorship across the ADCC, Rush University of the Rush ADCC strategic partners.

## Key facts

- **NIH application ID:** 9977065
- **Project number:** 5P30AG010161-30
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** DAVID ALAN BENNETT
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $3,522,718
- **Award type:** 5
- **Project period:** 1997-08-15 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977065

## Citation

> US National Institutes of Health, RePORTER application 9977065, Rush Alzheimer's Disease Core Center (5P30AG010161-30). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/9977065. Licensed CC0.

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