# Core G: Brain Imaging and Fluid Biomarkers Core

> **NIH NIH P30** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2020 · $1,225,545

## Abstract

Core Project Summary/Abstract
In this competitive revision we propose to establish a new Brain Imaging and Fluid Biomarkers (BI-FB) Core
to support neuroimaging and biomarker efforts in the [Arizona Alzheimer's Disease Core Center (ADCC)] and
the acquisition and analysis of neuroimaging data—including amyloid-β (Aβ) positron emission tomography
(PET) using 11C Pittsburgh compound B (PiB) [and 18F Florbetapir], tau PET using [18F Flortaucipir], and
magnetic resonance imaging (MRI)—and the collection, preparation, storage and analysis of fluid biomarkers
(including [cerebrospinal fluid (CSF)] Aβ42, t-tau and p-tau). This proposed core will provide new neuroimaging
and fluid biomarker support for the Arizona ADCC and [will maximally leverage the center's existing strengths
in: 1) advanced neuroimaging methods and analysis; 2) the ADCC core resources providing clinically well-
characterized and tracked participants with Alzheimer's disease (AD) and mild cognitive impairment (MCI), as
well as cognitively unimpaired individuals; and 3) the ancillary core resource of cognitively unimpaired Brain
Body Donation Program (BBDP) enrollees who have agreed to undergo postmortem neuropathological
examination. The supplemental specific aims of the application include: 1) to provide access to standardized
acquisition, processing, collection, and storage of amyloid-β (Aβ) and tau PET, MRI scans, and CSF and blood
samples across the Arizona ADCC; 2) to make available for research neuroimaging data and fluid biomarker
samples from clinically well-characterized AD, MCI, and cognitively unimpaired participants who have agreed
to have postmortem neuropathological evaluations; 3) to provide a resource of expertise and support for the
acquisition, processing, and analysis of brain images for use in research studies to support the goals and
mission of the Arizona ADCC and the NIA ADCC program nationally; and 4) to foster collaborative research by
working closely with and supporting researchers in each of the other Arizona ADCC Cores, as well as users of
these core resources inside and outside Arizona]. This new core will significantly extend the aims of the ADCC
and capitalize on its most unique and innovative strengths. It will also provide needed expertise and support for
neuroimaging and fluid biomarker studies to enhance the mission of our ADCC to detect and track preclinical
AD and ultimately to support the goal of finding effective AD prevention therapies.

## Key facts

- **NIH application ID:** 9977068
- **Project number:** 5P30AG019610-21
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** GENE E ALEXANDER
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,225,545
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977068

## Citation

> US National Institutes of Health, RePORTER application 9977068, Core G: Brain Imaging and Fluid Biomarkers Core (5P30AG019610-21). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977068. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*