# Core D: Neuropathology Core

> **NIH NIH P30** · ARIZONA STATE UNIVERSITY-TEMPE CAMPUS · 2020 · $241,330

## Abstract

NEUROPATHOLOGY CORE (CORE D) - PROJECT SUMMARY/ABSTRACT
The Neuropathology Core (NPC) is an essential part of the Alzheimer's Disease Core Center (ADCC). During
life, the signs and symptoms of Alzheimer's disease (AD) are not sufficiently different from several other
conditions, resulting in misdiagnosis, even at the most advanced centers, in about 20-30% of subjects.
Examination of the brain after death by a certified Neuropathologist is therefore the only means by which a
definite diagnosis can be attained, allowing all research results to be correctly interpreted. A second major role
of the NPC is to provide neuropathologically characterized brain tissue to basic scientists, both within the
ADCC and outside it, enabling them to discover the underlying molecular mechanisms of disease and design
appropriate therapeutic interventions. A detailed understanding of the genetic and molecular processes of
disease pathogenesis, obtained by comparative study of diseased and non-diseased brain tissue, remains the
major approach to finding such interventions. A third important goal of the NPC is to help develop a
collaborative synergy that will enhance the research productivity of the entire Center. Our Specific Aims are as
follows: 1) To provide precise neuropathologic diagnoses of patients that have been clinically studied by the
Clinical Core. 2) To provide basic scientists with neuropathologically characterized brain tissue suitable for the
elucidation of the molecular mechanisms of AD and related disorders, and especially to assist researchers in
their studies of the earliest stages of Alzheimer's disease, with the goal of identifying therapeutic strategies that
will prevent the disease or slow its progress. 3) To share neuropathological skills, expertise, knowledge and
data with all ADCC investigators and the scientific community at large, facilitating a collaborative synergy that
will enhance the research productivity of all.

## Key facts

- **NIH application ID:** 9977077
- **Project number:** 5P30AG019610-21
- **Recipient organization:** ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
- **Principal Investigator:** THOMAS G BEACH
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $241,330
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977077

## Citation

> US National Institutes of Health, RePORTER application 9977077, Core D: Neuropathology Core (5P30AG019610-21). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/9977077. Licensed CC0.

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