# Core B: Clinical Core

> **NIH NIH P30** · RUSH UNIVERSITY MEDICAL CENTER · 2020 · $418,974

## Abstract

ABSTRACT – CLINICAL CORE
The overall goal of the Clinical Core is to generate data and biospecimens to support high quality, cutting edge,
externally-funded clinical, epidemiologic, neurobiologic, and biomarker studies of aging that focus on better
defining normal aging and the transition from normal aging to mild cognitive impairment (MCI) to the earliest
stages of dementia among older Blacks. The Clinical Core has demonstrated expertise and success in
conducting studies with older persons under-represented in aging research. It provides participants, clinical
data, and biospecimens (brain tissue, DNA, and blood) to support a wide variety of studies by investigators at
Rush and across the county, particularly those that historically have had limited data from diverse groups (e.g.,
neuroimaging, genomics, epigenomics, proteomics, and metabolomics). The Core will continue to recruit,
enroll, and perform annual clinical evaluations including the UDS and tests that are compatible with the
Religious Orders Study and Latino Cores, on older Blacks without dementia, and increase awareness of the
importance of brain donation through culturally-tailored educational programs. This Core represents one of the
largest sources of brain tissue from older Blacks in the U.S. By focusing on older Blacks, a population at high
risk for AD, to provide clinical data, brain tissue, and DNA, the Clinical Core will continue to serve as a vital
resource to the wider aging and AD research community, not only for advancing the science of recruitment and
inclusion for under-represented populations in research, but also for addressing health disparities for one of the
most feared diseases of our time.

## Key facts

- **NIH application ID:** 9977088
- **Project number:** 5P30AG010161-30
- **Recipient organization:** RUSH UNIVERSITY MEDICAL CENTER
- **Principal Investigator:** Lisa L Barnes
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $418,974
- **Award type:** 5
- **Project period:** — → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/9977088

## Citation

> US National Institutes of Health, RePORTER application 9977088, Core B: Clinical Core (5P30AG010161-30). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/9977088. Licensed CC0.

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